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Gene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients

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dc.contributor.author김상철-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author서민영-
dc.contributor.author신지현-
dc.contributor.author양상화-
dc.contributor.author정하진-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2017-10-26T06:18:55Z-
dc.date.available2017-10-26T06:18:55Z-
dc.date.issued2005-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150784-
dc.description.abstractPURPOSE: This study examined the gene copy number change events at chromosome 20 in gastric cancer, and their possible relationship with recurrence using cDNA microarray-based comparative genomic hybridization. EXPERIMENTAL DESIGN: Thirty pairs of gastric tumor and normal gastric tissues were used in the cDNA microarray-based comparative genomic hybridization. The cDNA microarrays containing 17,000 sequence-verified human gene probes were used in a direct comparison design, where genomic DNAs from the normal and tumor tissues were labeled with fluorescent dyes Cy3 and Cy5, respectively, and cohybridized. Genes with log(2) (Cy5/Cy3) > or = 0.58 in at least one case were selected as the amplified genes. In order to search for the association between gene copy number changes and the recurrence status, patients were grouped according to their recurrence status. Gene selection between the two groups was done, and each patient was given a score based on the sum of the selected genes' ratios. Logistic regression analysis was carried out in order to determine if the score of a group of patients was correlated with a recurrence. RESULTS: A group of genes including NCOA6, CYP24A1, PTPN1, and ZNF217 was amplified in gastric cancer. Another group of 39 genes, whose sum of copy number change levels was significantly associated with a poor prognosis for recurrence, was selected (P < 0.05). CONCLUSION: Ninety-six amplified genes at chromosome 20 of gastric cancer are reported. A scoring system based on gene copy changes at chromosome 20 can provide an independent patient grouping system that can distinguish patient recurrence status and survival.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHChromosomes, Human, Pair 20/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGastric Mucosa/metabolism-
dc.subject.MESHGene Dosage*-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMale-
dc.subject.MESHNeoplasm Recurrence, Local/genetics*-
dc.subject.MESHNeoplasm Recurrence, Local/metabolism-
dc.subject.MESHNucleic Acid Hybridization-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach/pathology-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHSurvival Rate-
dc.titleGene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeResearch Institutes (연구소)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentCancer Metastasis Research Center (암전이연구센터)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSang Hwa Yang-
dc.contributor.googleauthorMin Young Seo-
dc.contributor.googleauthorHa Jin Jeong-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorJihye Shin-
dc.contributor.googleauthorSang Chul Kim-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doiOAK-2005-04736-
dc.contributor.localIdA00530-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA01880-
dc.contributor.localIdA02163-
dc.contributor.localIdA02288-
dc.contributor.localIdA03757-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.relation.journalcodeJ00564-
dc.identifier.pmid15701848-
dc.subject.keyword15701848-
dc.contributor.alternativeNameKim, Sang Chul-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameSeo, Min Young-
dc.contributor.alternativeNameShin, Ji Hyun-
dc.contributor.alternativeNameYang, Sang Hwa-
dc.contributor.alternativeNameJeong, Ha Jin-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.citation.volume11-
dc.citation.number2pt1-
dc.citation.startPage612-
dc.citation.endPage620-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.11(2pt1) : 612-620, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid44749-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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