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Immunoglobulin E Binding Reactivity of a Recombinant Allergen Homologous to α-Tubulin from Tyrophagus putrescentiae

Authors
 Kyoung Yong Jeong  ;  Haeseok Lee  ;  Jae Sik Lee  ;  Jongweon Lee  ;  In-Yong Lee  ;  Han-Il Ree  ;  Chein-Soo Hong  ;  Jung Won Park  ;  Tai-Soon Yong 
Citation
 Clinical and Diagnostic Laboratory Immunology, Vol.12(12) : 1451-1454, 2005 
Journal Title
 Clinical and Diagnostic Laboratory Immunology 
ISSN
 1071-412X 
Issue Date
2005
Abstract
Storage mites may cause allergic respiratory diseases in urban areas as well as pose an occupational hazard in rural areas. Characterization of storage mite allergens is important for the development of diagnostic and therapeutic agents against mite-associated allergic disorders. Here we report on the cloning and expression of α-tubulin from the storage mite (Tyrophagus putrescentiae). The deduced amino acid sequence of the α-tubulin from the storage mite showed as much as 97.3% identity to the α-tubulin sequences from other organisms. The highly conserved amino acid sequences of α-tubulins across different species of mites may indicate that cross-reactivity for this potential allergen exists. The frequency of immunoglobulin E reactivity of this recombinant protein is 29.3% in sera from storage mite-allergic subjects.
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DOI
10.1128/CDLI.12.12.1451-1454.2005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Lee, In Yong(이인용)
Lee, Jae Sik(이재식)
Lee, Jong Weon(이종원)
Ree, Han Il(이한일)
Lee, Hae Seok(이해석)
Jeong, Kyoung Yong(정경용) ORCID logo https://orcid.org/0000-0001-9887-1426
Hong, Chein Soo(홍천수)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150647
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