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Ectopic expression of vasopressin V1b and V2 receptors in the adrenal glands of familial ACTH-independent macronodular adrenal hyperplasia

DC FieldValueLanguage
dc.contributor.author김대중-
dc.contributor.author이시훈-
dc.contributor.author이유미-
dc.contributor.author이준호-
dc.contributor.author임승길-
dc.date.accessioned2017-10-26T06:11:08Z-
dc.date.available2017-10-26T06:11:08Z-
dc.date.issued2005-
dc.identifier.issn0300-0664-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150621-
dc.description.abstractOBJECTIVE: ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare and unusual cause of Cushing's syndrome, characterized by bilateral nodular adrenocortical hyperplasia and hypersecretion of cortisol. Familial AIMAH has rarely been reported. Recently, the aberrant expression of adrenal receptors for various ligands in AIMAH patients has become important in explaining the pathogenesis of AIMAH. In this study, we present the cases of two sisters who were affected with AIMAH. PATIENTS AND MEASUREMENTS: Two sisters, aged 46 and 58, respectively, at the time of diagnosis, were found to have Cushing's syndrome due to AIMAH. We performed provocation tests with various materials and reverse transcription polymerase chain reaction (RT-PCR) with their resected adrenal tissues to examine the hyper-responsiveness to steroidogenesis and the overexpression of related receptors, respectively. RESULTS: Provocation tests in vivo indicated that arginine vasopressin (AVP) promoted cortisol secretion through vasopressin V1a as well as V1b and V2 receptors. RT-PCR analysis revealed an abnormal cDNA expression of vasopressin V1b and V2 receptors, none of which is known to be normally expressed in the adrenal glands. CONCLUSION: The expression of ectopic vasopressin V1b and V2 receptors may be involved in the aetiology of AIMAH, at least in the case of the sibling patients presented here.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Publishing-
dc.relation.isPartOfCLINICAL ENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdrenal Glands/diagnostic imaging-
dc.subject.MESHAdrenal Glands/metabolism*-
dc.subject.MESHAdrenal Hyperplasia, Congenital/diagnostic imaging-
dc.subject.MESHAdrenal Hyperplasia, Congenital/genetics*-
dc.subject.MESHAdrenal Hyperplasia, Congenital/metabolism*-
dc.subject.MESHArginine Vasopressin-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHHumans-
dc.subject.MESHHydrocortisone/blood-
dc.subject.MESHHydrocortisone/metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPedigree-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHReceptors, Vasopressin/genetics-
dc.subject.MESHReceptors, Vasopressin/metabolism*-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleEctopic expression of vasopressin V1b and V2 receptors in the adrenal glands of familial ACTH-independent macronodular adrenal hyperplasia-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSihoon Lee-
dc.contributor.googleauthorRanjoo Hwang-
dc.contributor.googleauthorJunho Lee-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorDae Jung Kim-
dc.contributor.googleauthorUng-il Chung-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi10.1111/j.1365-2265.2005.02387.x-
dc.contributor.localIdA00369-
dc.contributor.localIdA02942-
dc.contributor.localIdA03012-
dc.contributor.localIdA03181-
dc.contributor.localIdA03375-
dc.relation.journalcodeJ00571-
dc.identifier.eissn1365-2265-
dc.identifier.pmid16343095-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2005.02387.x/abstract-
dc.subject.keyword16343095-
dc.contributor.alternativeNameKim, Dae Jung-
dc.contributor.alternativeNameLee, Si Hoon-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLee, Jun Ho-
dc.contributor.alternativeNameLim, Sung Kil-
dc.citation.volume63-
dc.citation.number6-
dc.citation.startPage625-
dc.citation.endPage630-
dc.identifier.bibliographicCitationCLINICAL ENDOCRINOLOGY, Vol.63(6) : 625-630, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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