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응급실에서 Ketamine을 이용한 소아 진정시 Midazolam병용의 효과

Other Titles
 The Clinical Effects of Adjunctive Midazolam During Ketamine Procedural Sedation in Pediatric Emergency Patients 
 이진희  ;  유제성  ;  조영순  ;  윤유상  ;  박준석  ;  이한식  ;  조광현 
 Journal of the Korean Society of Emergency Medicine (대한응급의학회지), Vol.16(1) : 78-82, 2005 
Journal Title
Journal of the Korean Society of Emergency Medicine(대한응급의학회지)
Issue Date
ketamin ; midazolam ; pediatric sedation
ketamin ; midazolam ; pediatric sedation
Purpose: Despite widespread use of adjunctive benzodiazepines during ketamine sedation, their efficacy in children has never been studied in Korea. We compared the clinical characteristics and the side effects of as well as the physic i a n’s satisfaction with, ketamine sedation in pediatric patients undergoing procedures involving ketamine with adjunctive midazolam.

Methods: The study was a prospective, randomized, clinical evaluation of the effect of adjunctive midazolam during ketamine sedation. We enrolled 60 children aged 8 months to 8 years. Subjects received either intramuscular ketamine (3 mg/kg) with atropine (0.01 mg/kg) (KA) or intramuscular midazolam (0.05 mg/kg) with ketamine and atropine (KMA). For the two groups, we evaluated the induction time, the recovery time, the sedation efficacy, the adverse effects, and the treating physicians’ satisfaction.

Results: Forty-two (42) subjects received KMA, and 18 received KA. Potentially confounding variables were similar between the two groups, and the induction times and the recovery times were equivalent. The addition of midazolam led to better sedation efficacy (KA=18.8% versus KMA= 55.0%), more treating physician satisfaction (KA=35.4% versus KMA=69.2%), and a decreased incidence of recovery agitation (KA=27.8% versus KMA= 4.7%).

Conclusion: The incidence of emergence phenomena and satisfaction was affected by the addition of midazolam. The addition of midazolam during ketamine sedation is efficacious and safe with high physician satisfaction for sedation of pediatric patients in the Emergency Department.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
Park, Jun Seog(박준석)
Yoon, Yoo Sang(윤유상)
Lee, Jin Hee(이진희)
Lee, Hahn Shick(이한식)
Cho, Young Soon(조영순)
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