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Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

Authors
 Seung-Soon Im  ;  Jae-Woo Kim  ;  Tae-Hyun Kim  ;  Xian-Li Song  ;  So-Youn Kim  ;  Ha-Il Kim  ;  Yong-Ho Ahn 
Citation
 Experimental and Molecular Medicine, Vol.37(2) : 101-110, 2005 
Journal Title
 Experimental and Molecular Medicine 
ISSN
 1226-3613 
Issue Date
2005
Abstract
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-γ in the liver. Rosiglitazone, PPAR-γ agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-γ/RXR-α. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-γ rather than PPAR-α binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-γ ligand contributing to glucose transport into liver in a condition when PAPR-γ expression is increased as in type 2 diabetes or in severe obesity.
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DOI
10.1038/emm.2005.14
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
김소연(Kim, So Youn)
김재우(Kim, Jae Woo) ORCID logo https://orcid.org/0000-0001-5456-9495
김태현(Kim, Tae Hyun)
김하일(Kim, Ha Il)
송현려(Song, Xian Li)
안용호(Ahn, Yong Ho) ORCID logo https://orcid.org/0000-0002-4133-0757
임승순(Im, Seung Soon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150036
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