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Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

DC FieldValueLanguage
dc.contributor.author김소연-
dc.contributor.author김재우-
dc.contributor.author김태현-
dc.contributor.author김하일-
dc.contributor.author송현려-
dc.contributor.author안용호-
dc.contributor.author임승순-
dc.date.accessioned2017-09-30T06:33:40Z-
dc.date.available2017-09-30T06:33:40Z-
dc.date.issued2005-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/150036-
dc.description.abstractIn the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-γ in the liver. Rosiglitazone, PPAR-γ agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-γ/RXR-α. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-γ rather than PPAR-α binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-γ ligand contributing to glucose transport into liver in a condition when PAPR-γ expression is increased as in type 2 diabetes or in severe obesity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChromatin Immunoprecipitation-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenes, Reporter-
dc.subject.MESHGlucose Transporter Type 2-
dc.subject.MESHHepatocytes/metabolism*-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHMonosaccharide Transport Proteins/biosynthesis*-
dc.subject.MESHMonosaccharide Transport Proteins/genetics-
dc.subject.MESHMutagenesis, Site-Directed-
dc.subject.MESHPPAR alpha/genetics-
dc.subject.MESHPPAR alpha/metabolism-
dc.subject.MESHPPAR gamma/agonists-
dc.subject.MESHPPAR gamma/genetics-
dc.subject.MESHPPAR gamma/metabolism*-
dc.subject.MESHPromoter Regions, Genetic*-
dc.subject.MESHProtein Isoforms/biosynthesis-
dc.subject.MESHResponse Elements*-
dc.subject.MESHRosiglitazone-
dc.subject.MESHThiazolidinediones/pharmacology-
dc.titleIdentification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorSeung-Soon Im-
dc.contributor.googleauthorJae-Woo Kim-
dc.contributor.googleauthorTae-Hyun Kim-
dc.contributor.googleauthorXian-Li Song-
dc.contributor.googleauthorSo-Youn Kim-
dc.contributor.googleauthorHa-Il Kim-
dc.contributor.googleauthorYong-Ho Ahn-
dc.identifier.doi10.1038/emm.2005.14-
dc.contributor.localIdA00617-
dc.contributor.localIdA00865-
dc.contributor.localIdA01081-
dc.contributor.localIdA01092-
dc.contributor.localIdA02075-
dc.contributor.localIdA02249-
dc.contributor.localIdA03376-
dc.relation.journalcodeJ00860-
dc.identifier.eissn2092-6413-
dc.identifier.pmid15886523-
dc.subject.keyword15886523-
dc.contributor.alternativeNameKim, So Youn-
dc.contributor.alternativeNameKim, Jae Woo-
dc.contributor.alternativeNameKim, Tae Hyun-
dc.contributor.alternativeNameKim, Ha Il-
dc.contributor.alternativeNameSong, Xian Li-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.alternativeNameIm, Seung Soon-
dc.citation.volume37-
dc.citation.number2-
dc.citation.startPage101-
dc.citation.endPage110-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.37(2) : 101-110, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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