Cited 29 times in
Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김재우 | - |
dc.contributor.author | 김태현 | - |
dc.contributor.author | 김하일 | - |
dc.contributor.author | 송현려 | - |
dc.contributor.author | 안용호 | - |
dc.contributor.author | 임승순 | - |
dc.date.accessioned | 2017-09-30T06:33:40Z | - |
dc.date.available | 2017-09-30T06:33:40Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150036 | - |
dc.description.abstract | In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-γ in the liver. Rosiglitazone, PPAR-γ agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-γ/RXR-α. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-γ rather than PPAR-α binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-γ ligand contributing to glucose transport into liver in a condition when PAPR-γ expression is increased as in type 2 diabetes or in severe obesity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chromatin Immunoprecipitation | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Genes, Reporter | - |
dc.subject.MESH | Glucose Transporter Type 2 | - |
dc.subject.MESH | Hepatocytes/metabolism* | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Monosaccharide Transport Proteins/biosynthesis* | - |
dc.subject.MESH | Monosaccharide Transport Proteins/genetics | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | PPAR alpha/genetics | - |
dc.subject.MESH | PPAR alpha/metabolism | - |
dc.subject.MESH | PPAR gamma/agonists | - |
dc.subject.MESH | PPAR gamma/genetics | - |
dc.subject.MESH | PPAR gamma/metabolism* | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | Protein Isoforms/biosynthesis | - |
dc.subject.MESH | Response Elements* | - |
dc.subject.MESH | Rosiglitazone | - |
dc.subject.MESH | Thiazolidinediones/pharmacology | - |
dc.title | Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.googleauthor | Seung-Soon Im | - |
dc.contributor.googleauthor | Jae-Woo Kim | - |
dc.contributor.googleauthor | Tae-Hyun Kim | - |
dc.contributor.googleauthor | Xian-Li Song | - |
dc.contributor.googleauthor | So-Youn Kim | - |
dc.contributor.googleauthor | Ha-Il Kim | - |
dc.contributor.googleauthor | Yong-Ho Ahn | - |
dc.identifier.doi | 10.1038/emm.2005.14 | - |
dc.contributor.localId | A00617 | - |
dc.contributor.localId | A00865 | - |
dc.contributor.localId | A01081 | - |
dc.contributor.localId | A01092 | - |
dc.contributor.localId | A02075 | - |
dc.contributor.localId | A02249 | - |
dc.contributor.localId | A03376 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 15886523 | - |
dc.subject.keyword | 15886523 | - |
dc.contributor.alternativeName | Kim, So Youn | - |
dc.contributor.alternativeName | Kim, Jae Woo | - |
dc.contributor.alternativeName | Kim, Tae Hyun | - |
dc.contributor.alternativeName | Kim, Ha Il | - |
dc.contributor.alternativeName | Song, Xian Li | - |
dc.contributor.alternativeName | Ahn, Yong Ho | - |
dc.contributor.alternativeName | Im, Seung Soon | - |
dc.citation.volume | 37 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 110 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.37(2) : 101-110, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42718 | - |
dc.type.rims | ART | - |
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