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소아 및 청소년 비만증에서 인슐린 저항성에 미치는 요인

Other Titles
 Affecting Factors of Insulin Resistance in Obese Children and Adolescents 
 김덕희  ;  은호선  ;  최인경  ;  김호성  ;  차봉수  ;  김동기 
 Korean Journal of Pediatrics, Vol.48(10) : 1076-1081, 2005 
Journal Title
Korean Journal of Pediatrics
Issue Date
Childhood obesity ; Adolescent obesity ; Insulin resistance ; Impaired glucose tolerance
Childhood obesity ; Adolescent obesity ; Insulin resistance ; Impaired glucose tolerance
Purpose: Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance(IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance.

Methods: Of the 9,837 school children from 5 to 16 tears old, 92 obese children and 187 adolescent, underwent a two-hour oral glucose tolerance test and plasma glucose, insulin, lipid profiles, leptin and high sensitive C-reactive protein(hs-CRP) were measure.

Results: Plasma insulin levels of female were higher compared to those of males during oral glucose tolerance test(P<0.05). Four(4.3%) in obese children and twenty five(13.3%) in obese adolescents met the criteria of IGT. Female, leptin, adiponectin and triglyceride concentrations were strongly correlated with homeostatic model assessment insulin-resistance(HOMA-IR) by multiple linear regression analysis(P<0.05).

Conclusion: Obese adolescents might have higher insulin concentrations compared to obese children and obese girls higher insulin concentrations than obese boys. Obese boys and children with impaired glucose tolerance have higher insulin concentrations than those with normal glucose tolerance. HOMA-IR was significantly correlated with female, plasma leptin, adiponectin and triglyceride concentrations.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Dong Ki(김동기)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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