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Serial Assessment of Myocardial Properties Using Cyclic Variation of Integrated Backscatter in an Adriamycin-Induced Cardiomyopathy Rat Model

 Jong-Won Ha  ;  Seok-Min Kang  ;  Wook-Bum Pyun  ;  Joo-Yong Lee  ;  Mi-Young Ahn  ;  Woong-Chul Kang  ;  Tae Joo Jeon  ;  Namsik Chung  ;  Jong-Doo Lee  ;  Sang-Ho Cho 
 YONSEI MEDICAL JOURNAL, Vol.46(1) : 73-77, 2005 
Journal Title
Issue Date
Animals ; Antibiotics, Antineoplastic/toxicity* ; Cardiomyopathies/chemically induced* ; Cardiomyopathies/diagnostic imaging* ; Disease Models, Animal ; Doxorubicin/toxicity* ; Echocardiography* ; Male ; Rats ; Rats, Wistar
Anthracycline ; cardiotoxicity ; echocardiography
Although adriamycin (Doxorubicin) is one of the most effective and useful antineoplastic agents for the treatment of a variety of malignancies, its repeated administration can induce irreversible myocardial damage and resultant heart failure. Currently, no marker to detect early cardiac damage is available. The purpose of this study was to investigate whether an assessment of the acoustic properties of the myocardium could enable the earlier detection of myocardial damage after adriamycin chemotherapy. Forty Wistar rats were treated with adriamycin (2 mg/kg, i.v.) once a week for 2, 4, 6 or 8 weeks consecutively. Left ventricular ejection fraction (LVEF) was calculated using M-mode echocardiography data. The magnitude of cardiac cycle dependent variation of integrated backscatter (CVIB) of the myocardium was measured in the mid segment of the septum and in the posterior wall of the left ventricle, using a real time two dimensional integrated backscatter imaging system. LVEF was significantly lower in the adriamycin-treated 8-week group than in the controls (75 ± 9 vs 57 ± 8%, p < 0.05). Myocyte damage was only seen in the 8-week adriamycin-treated group. However, no significant changes of CVIB were observed between baseline or during follow-up in the ADR or control group. In conclusion, serial assessment of the acoustic properties of the myocardium may not be an optimal tool for the early detection of myocardial damage after doxorubicin chemotherapy in a rat model.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Lee, Jong Doo(이종두)
Chung, Nam Sik(정남식)
Cho, Sang Ho(조상호)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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