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한국인에서 5-HT1Dβ 유전자다형성과 성격 특성

Other Titles
 Polymorphisms in 5-HT1Dβ Receptor Gene and Personality Traits in a Korean Population 
 김세주  ;  김찬형  ;  최낙경  ;  홍현주  ;  김성준  ;  조대연  ;  이홍식 
 Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.44(2) : 185-190, 2005 
Journal Title
 Journal of the Korean Neuropsychiatric Association (신경정신의학) 
Issue Date
Objectives: Recently, there has been a growing enthusiasm in biological approach to personality; the identification of genes responsible for particular personality traits. The aim of this study was to investigate the association between the 5-HT1Dbeta G861C polymorphism and personality traits. Methods: We recruited 218 normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the HT1Dbeta G861C polymorphism was genotyped by means of polymerase chain reaction and Homogeneous MassEXTEND method. We classified the subject into the GG, CG, and GG groups according to their genotypes. The differences in the temperament factors of the TCI between homozygote group (GG+CC genotype) and heterozygote group (CG genotype) were tested. Results: The heterozygote group had significantly lower Harm avoidance (HA) scores and higher Self-directedness scores (SD) than the homozygote group. Conclusion: In conclusion, we found some associations between the 5-HT1Dbeta G861C polymorphism and the personality dimension HA and SD in a normal population.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Nam, Yoon Young(남윤영)
Lee, Hong Shick(이홍식)
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