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전립선암의 진단에 있어서 전립선 재생검의 의의

Other Titles
 Significance of Repeat Prostate Biopsy for Detection of Prostate Cancer 
 박은기  ;  양원재  ;  최영득  ;  정병하  ;  나군호  ;  양승철  ;  마상열  ;  홍성준 
 KOREAN JOURNAL OF UROLOGY, Vol.46(12) : 1268-1271, 2005 
Journal Title
Issue Date
Biopsy ; Prostate cancer ; Prostate-specific antigen
Biopsy ; Prostate cancer ; Prostate-specific antigen
Purpose: To evaluate the results of serial prostate biopsy in men with elevated prostate-specific antigen(PSA) levels, where the initial biopsies were negative for cancer.
Materials and Methods: Between January 2000 and December 2003, 750 men with a serum PSA level of 4.0ng/ml or greater underwent transrectal ultrasound guided needle biopsy of the prostate, with 218(29.1%) diagnosed as having prostate cancer. Of the other 532 men, 104(19.5%), whose follow-up PSA level was persistently elevated beyond the normal range, underwent a second biopsy, with 26(4.9%) undergoing third and subsequent biopsies for the same reason. The cancer detection rates after each biopsy session, and reliable predictors for prostate cancer after the 2nd biopsy in those whose PSA level was in the gray zone, were evaluated.
Results: The cancer detection rates of the 1st, 2nd and 3rd biopsies were 29.1, 16.3 and 30.7%, respectively, with 10.3% of the prostate cancers detected in this study missed on the initial biopsy. The detection rate of the second biopsy in gray zone patients was 13.1%, which was comparable to the first biopsy result(12.7%) for the same range group. The median PSA, % free PSA and PSA density were significantly different between the prostate cancer and non-cancer groups after the second biopsy in gray zone patients(p<0.05).
Conclusions: 10.3% of the prostate cancers detected in this study were missed on the initial biopsy. The median PSA, % free PSA and PSA density are reliable predictors of prostate cancer after the second biopsy in gray zone patients
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Mah, Sang Yol(마상열)
Yang, Seung Choul(양승철)
Yang, Won Jae(양원재)
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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