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Is high-sensitivity C-reactive protein associated with carotid atherosclerosis in healthy Koreans?

Other Titles
 Is high-sensitivity C-reactive protein associated with carotid atherosclerosis in healthy Koreans? 
Authors
 Sung Hee Choi  ;  Hyeon Chang Kim  ;  Chul Woo Ahn  ;  Hong Keun Cho  ;  Bong Soo Cha  ;  Yoon-Sok Chung  ;  Kwan Woo Lee  ;  Hyun Chul Lee  ;  Kap Bum Huh  ;  Dae-Jung Kim 
Citation
 European Journal of Cardiovascular Prevention & Rehabilitation, Vol.12(6) : 548-554, 2005 
Journal Title
 European Journal of Cardiovascular Prevention & Rehabilitation 
ISSN
 1741-8267 
Issue Date
2005
Abstract
BACKGROUND: There is a positive association between chronic inflammation and the risk of cardiovascular disease, but whether there is an association between C-reactive protein (CRP) and carotid atherosclerosis is controversial. We investigated the relationship between high-sensitivity CRP (hsCRP) levels and carotid intima-media thickness (IMT) in healthy Koreans. DESIGN: We measured hsCRP levels, the carotid IMT, and conventional cardiovascular risk factors including obesity parameters, blood pressure, lipid profiles, insulin resistance, and smoking habits in 820 volunteers (35-79 years old) in a cross-sectional study. RESULTS: Higher hsCRP quartile groups had higher mean IMTs, as compared with the lowest quartile (P < 0.001 for the trend across quartiles). However, after adjustment for age, the relationship between hsCRP level and IMT was substantially weaker (P = 0.018). After additional adjustments for conventional cardiovascular risk factors, no significant association was observed (P = 0.548). The unadjusted risk for a high carotid IMT value (> or = 1.0 mm) was also positively related to hsCRP quartile, but this relationship was not significant after adjustment for age and other cardiovascular risk factors. CONCLUSIONS: Both hsCRP levels and the carotid IMT were strongly correlated with conventional cardiovascular risk factors, but there was no independent association between hsCRP levels and carotid IMT in healthy Korean adults.
Full Text
http://cpr.sagepub.com/content/12/6/548.long
DOI
10.1097/01.hjr.0000183915.28354.b2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cho, Hong Keun(조홍근)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Huh, Kap Bum(허갑범)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149933
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