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강박장애와 도파민 D4 수용체 유전자형과의 연관성

Other Titles
 Association between Obsessive-Compulsive Disorder and Dopamine Receptor D4 Gene 
Authors
 김세주  ;  유상우  ;  남윤영  ;  이홍식  ;  김찬형 
Citation
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.16(6) : 513-520, 2005 
Journal Title
Korean Journal of Psychopharmacology(대한정신약물학회지)
ISSN
 1017-5717 
Issue Date
2005
MeSH
Dopamine receptor D4 ; Dopamine transporter ; Genotype ; OCD
Keywords
Dopamine receptor D4 ; Dopamine transporter ; Genotype ; OCD
Abstract
Objective : The definite causes of obsessive-compulsive disorder (OCD) are still unknown. Evidences from familial, twin and segregation studies support the role of a genetic component in the etiology of OCD. There are growing evidences that OCD has specific neurochemical and neuroanatomical basis. It has been shown that serotonergic neurons play the predominant pathophysiological role in OCD. Recently, it has also been proposed that neurotransmitters other than serotonin play a role in the pathophysiology of OCD, and a series of studies have provided evidence that dopamine is involved in some OCD patients. Therefore, the aims of this study were to investigate the association between dopamine receptor D4 (DRD4) and OCD.
Methods : One hundred and fifteen OCD patients and 160 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the DRD4 polymorphism between OCD group and control group were compared. OCD patients were classified into early onset group (age of onset <17) and late onset group (age of onset ≥17) according to their onset age and the genotype and allele frequency were compared between two groups. Using principal component analysis, we had already derived 4 factors from 13 main contents of YBOCS checklist in the previous study and in this study, we investigated the association between these three factors and DRD4 genotypes.
Results : In this case-control study, we could find that the L-genotype frequencies of DRD4 were significantly higher in OCD than in normal control groups (χ² test, p=0.04). There were no difference in genotype frequencies between early onset OCD group and late onset OCD group. In OCD group, patients with L-genotype had higher scores for the religious/somatic factor than the other groups (t test, p=0.009).
Conclusions : The Lgenotype of DRD4 may have negative effects on the development of OCD and religious/somatic factor of the obsessive-compulsive symptoms.
Files in This Item:
T200501628.pdf Download
DOI
OAK-2005-06698
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Chan Hyung(김찬형)
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149888
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