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Neural correlates for prospective memory decline in postpartum women

Other Titles
 출산 후 여성에서의 미래기억 능력 저하와 연관된 뇌활성화 변화 
Authors
 신나영 
Department
 Dept. of Radiology (영상의학교실) 
Issue Date
2016
Description
Dept. of Medicine/박사
Abstract
I. INTRODUCTION
Prospective memory (PM) refers to the ability to remember to execute delayed intention in appropriate situations. Although postpartum women have risk factors for decreased PM performance such as demanding ongoing tasks, depressive symptoms, and decreased serum levels of estrogen, there has been little research on PM in postpartum women. Therefore, the present study aimed to assess PM performance and to find out relevant functional and structural neural correlates in postpartum women. Variable clinical information was also obtained to establish possible causes for decreased PM performance in postpartum women.

II. MATERIALS AND METHODS
Twenty-five postpartum women aged 20-40 years in the 2nd - 4th month after parturition and 26 nulliparous women who were matched for age and education were prospectively enrolled. All participants underwent resting-state and PM task-based functional MRI (fMRI) and structural MRI, self-report questionnaires, neuropsychological tests, and hormone assays.

III. RESULTS
The postpartum women showed decreased PM performance compared to the controls, showing lower PM accuracy (P = .003) and longer reaction times (P = .003). On task-based fMRI analysis, the right hippocampus failed to show PM-related activation in postpartum women. On Psychophysiological Interaction analysis using the right hippocampus seed, postpartum women had decreased functional connectivity (FC) with ventral frontoparietal networks (FPN) in PM trials relative to PM ongoing trials (ongoing trials in the PM block), while the controls showed increased FC. Postpartum women also showed altered resting-state functional connectivity (RSFC) in the right hippocampus seed: decreased RSFC with the ventromedial prefrontal cortex, and increased RSFC with the ventrolateral prefrontal cortex, temporoparietal junction, and frontal eye field. No difference was found in cortical thickness or hippocampal volume between the groups. On multivariate analysis, the decreased FC between the right hippocampus and ventral FPN in PM trials relative to PM ongoing trials (odds ratio = 1.219, P = .035) and the higher number of nocturnal awakenings (odds ratio = 0.635, P < .001) were independent predictors for poor PM performance even after adjustments for age, duration of education, serum level of estrogen, and depressive symptoms.
IV. CONCLUSION
The present study showed decreased PM behavioral performance in postpartum women compared to the controls. Decreased FC within spontaneous retrieval-related regions including the right hippocampus and ventral FPN along with disrupted sleep rhythms may contribute to poor PM performance in postpartum women.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 3. Dissertation
Yonsei Authors
Shin, Na Young(신나영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149174
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