Sinus augmentation using BMP-2 in a bovine hydroxyapatite collagen carrier in dogs

Abstract

Objective

The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model.

Material and Methods

Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E.coli-derived BMP-2 at 0.1 mg/mL was implanted in 4 animals, and BHC loaded with E.coli-derived BMP-2 at 0.5 and 1.5 mg/mL was implanted in 4 animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses.

Results

Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control.

Conclusion

BMP-2 in a BHC carrier, even at the low 0.1-mg/mL concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.