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제2형 당뇨병을 동반한 급성기 열공성 뇌경색에서 박동성 지수의 증가

Other Titles
 Increased Pulsatility Index in Acute Lacunar Infarction with Type II Diabetes 
Authors
 이기욱  ;  박지형  ;  최영철  ;  한상원  ;  남효석  ;  허지회  ;  이경열 
Citation
 Journal of the Korean Neurological Association, Vol.23(4) : 457-462, 2005 
Journal Title
 Journal of the Korean Neurological Association 
ISSN
 1738-1428 
Issue Date
2005
MeSH
Aged ; Basilar Artery/diagnostic imaging ; Basilar Artery/physiology ; Brain/blood supply* ; Brain Infarction/complications ; Brain Infarction/diagnostic imaging* ; Diabetes Mellitus, Type 2/complications* ; Diabetic Angiopathies/diagnostic imaging* ; Female ; Humans ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging ; Middle Cerebral Artery/physiology ; Pulsatile Flow ; Retrospective Studies ; Ultrasonography, Doppler, Transcranial
Keywords
Diabetes mellitus ; lacunar infarction ; transcranial Doppler ; pulsatility index
Abstract
Background: The pulsatility index (PI) measured by a transcranial Doppler (TCD) has been postulated to reflect the vascular resistance that is distal to the artery being examined. Therefore, pathologies of small perforating arteries may affect the PI of the proximal artery. Microangiopathy is a common vascular complication of diabetes mellitus (DM), which may contribute to the development of small infarctions involving the perforating artery, and may be reflected on the PI. Methods: We enrolled patients with acute cerebral infarctions who were examined by TCD, MRI, and MRA and fulfilled the following criteria: 1)an infarction of less than 2 cm size involving a single perforating arterial territory; 2)no significant arterial stenosis on MRA; and 3)no cardioembolic sources. Patients were divided into either a group with DM, or without and TCD findings were compared. Results: The DM group showed higher PI than non-DM (0.99 v.s. 0.85 for the right middle cerebral artery; 1.02 v.s. 0.85 for the left middle cerebral artery; and 0.94 v.s. 0.78 for the basilar artery). The mean flow velocity was comparable between the groups. Multivariate linear regression analysis revealed that the duration of DM was a significant predictor of elevated PI of the bilateral MCA and basilar artery and that age was another significant predictor in the case of basilar artery. Conclusions: The elevated PIs in DM patients suggest the possible role of diabetic microvascular complications in the development of the lacunar infarction. The PI measurement using TCD may be a useful marker of the lacunar infarction, especially in DM patients
Files in This Item:
T200500420.pdf Download
DOI
10.3349/ymj.2007.48.5.802
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
Han, Sang Won(한상원)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147625
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