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White Blood Cell Count and Risk for All-Cause, Cardiovascular, and Cancer Mortality in a Cohort of Koreans

Authors
 Sun Ha Jee  ;  Jung Yong Park  ;  Hyon-Suk Kim  ;  Tae Yong Lee  ;  Jonathan M. Samet 
Citation
 AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol.162(11) : 1062-1069, 2005 
Journal Title
 AMERICAN JOURNAL OF EPIDEMIOLOGY 
ISSN
 0002-9262 
Issue Date
2005
MeSH
Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Alcohol Drinking/mortality ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/mortality* ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Korea/epidemiology ; Leukocyte Count/statistics & numerical data* ; Male ; Middle Aged ; Neoplasms/blood* ; Neoplasms/mortality* ; Prospective Studies ; Risk Factors ; Sex Distribution ; Smoking/mortality
Keywords
arteriosclerosis ; cardiovascular diseases ; death ; leukocytes ; neoplasms
Abstract
The authors conducted a 10-year prospective cohort study of mortality in relation to white blood cell counts of 437,454 Koreans, aged 40–95 years, who received health insurance from the National Health Insurance Corporation and were medically evaluated in 1993 or 1995, with white blood cell measurement. The main outcome measures were mortality from all causes, all cancers, and all atherosclerotic cardiovascular diseases (ASCVD). Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models with adjustment for age and potential confounders. During follow-up, 48,757 deaths occurred, with 15,507 deaths from cancer and 11,676 from ASCVD. For men and women, white blood cell count was associated with all-cause mortality and ASCVD mortality but not with cancer mortality. In healthy nonsmokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was observed in men (highest vs. lowest quintile: hazard ratio = 2.10, 95% confidence interval: 1.50, 2.94) and in women (hazard ratio = 1.35, 95% confidence interval: 1.17, 1.56). In healthy smokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was also observed in men (highest vs. lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality.
Files in This Item:
T200500375.pdf Download
DOI
10.1093/aje/kwi326
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147587
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