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Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

Authors
 Mi Jin Kim  ;  Young A. Yoo  ;  Hyung Jung Kim  ;  Seongman Kang  ;  Yong Geon Kim  ;  Jun Suk Kim  ;  Young Do Yoo 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.338(2) : 1179-1184, 2005 
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
 0006-291X 
Issue Date
2005
MeSH
Adenocarcinoma/metabolism* ; Carrier Proteins/metabolism* ; Cell Cycle Proteins/metabolism* ; Cell Line, Tumor ; Culture Media, Serum-Free ; Cyclin-Dependent Kinase Inhibitor p21/metabolism* ; G1 Phase* ; Humans ; Lung Neoplasms/metabolism* ; Mitochondrial Proteins ; Ribosomal Proteins/metabolism* ; Serum/metabolism
Keywords
MRPL41 ; p21WAF1/CIP1 ; Serum starvation ; p53 ; Cell cycle ; p27Kip1
Abstract
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X05023193
DOI
10.1016/j.bbrc.2005.10.064
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147571
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