Cited 34 times in
Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1
DC Field | Value | Language |
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dc.contributor.author | 김형중 | - |
dc.date.accessioned | 2017-05-04T07:38:19Z | - |
dc.date.available | 2017-05-04T07:38:19Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147571 | - |
dc.description.abstract | Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/metabolism* | - |
dc.subject.MESH | Carrier Proteins/metabolism* | - |
dc.subject.MESH | Cell Cycle Proteins/metabolism* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Culture Media, Serum-Free | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p21/metabolism* | - |
dc.subject.MESH | G1 Phase* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Mitochondrial Proteins | - |
dc.subject.MESH | Ribosomal Proteins/metabolism* | - |
dc.subject.MESH | Serum/metabolism | - |
dc.title | Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1 | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Mi Jin Kim | - |
dc.contributor.googleauthor | Young A. Yoo | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Seongman Kang | - |
dc.contributor.googleauthor | Yong Geon Kim | - |
dc.contributor.googleauthor | Jun Suk Kim | - |
dc.contributor.googleauthor | Young Do Yoo | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.10.064 | - |
dc.contributor.localId | A01158 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16256947 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05023193 | - |
dc.subject.keyword | MRPL41 | - |
dc.subject.keyword | p21WAF1/CIP1 | - |
dc.subject.keyword | Serum starvation | - |
dc.subject.keyword | p53 | - |
dc.subject.keyword | Cell cycle | - |
dc.subject.keyword | p27Kip1 | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.citation.volume | 338 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1179 | - |
dc.citation.endPage | 1184 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.338(2) : 1179-1184, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40344 | - |
dc.type.rims | ART | - |
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