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Small-diameter blood vessels engineered with bone marrow-derived cells
DC Field | Value | Language |
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dc.contributor.author | 김일권 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 임상현 | - |
dc.contributor.author | 장병철 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 홍유선 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2017-05-04T07:37:17Z | - |
dc.date.available | 2017-05-04T07:37:17Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147551 | - |
dc.description.abstract | OBJECTIVE: The objective of this study is to investigate if bone marrow-derived cells (BMCs) regenerate vascular tissues and improve patency in tissue-engineered small-diameter (internal diameter = 3 mm) vascular grafts. SUMMARY BACKGROUND DATA: BMCs have demonstrated the ability to differentiate into endothelial-like cells and vascular smooth muscle-like cells and may offer an alternative cell source for vascular tissue engineering. Thus, we tissue-engineered small-diameter vascular grafts with BMCs and decellularized arteries. METHODS: Canine BMCs were differentiated in vitro into smooth muscle alpha-actin/smooth muscle myosin heavy-chain-positive cells and von Willebrand factor/CD31-positive cells and seeded onto decellularized canine carotid arteries (internal diameter = 3 mm). The seeded grafts were implanted in cell donor dogs. The vascular-tissue regeneration and graft patency were investigated with immunohistochemistry and angiography, respectively. RESULTS: The vascular grafts seeded with BMCs remained patent for up to 8 weeks in the canine carotid artery interposition model, whereas nonseeded grafts occluded within 2 weeks. Within 8 weeks after implantation, the vascular grafts showed regeneration of the 3 elements of artery (endothelium, media, and adventitia). BMCs labeled with a fluorescent dye prior to implantation were detected in the retrieved vascular grafts, indicating that the BMCs participated in the vascular tissue regeneration. CONCLUSIONS: Here we show that BMCs have the potential to regenerate vascular tissues and improve patency in tissue-engineered small-diameter vascular grafts. This is the first report of a small-diameter neovessel engineered with BMCs as a cell source. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow Cells*/cytology | - |
dc.subject.MESH | Bone Marrow Cells*/physiology | - |
dc.subject.MESH | Carotid Arteries/physiology | - |
dc.subject.MESH | Carotid Arteries/transplantation* | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Endothelium, Vascular/cytology* | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Muscle, Smooth, Vascular/cytology* | - |
dc.subject.MESH | Regeneration | - |
dc.subject.MESH | Tissue Engineering* | - |
dc.subject.MESH | Vascular Patency | - |
dc.title | Small-diameter blood vessels engineered with bone marrow-derived cells | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Seung-Woo Cho | - |
dc.contributor.googleauthor | Sang Hyun Lim | - |
dc.contributor.googleauthor | Il-Kwon Kim | - |
dc.contributor.googleauthor | Yoo Sun Hong | - |
dc.contributor.googleauthor | Sang-Soo Kim | - |
dc.contributor.googleauthor | Kyung Jong Yoo | - |
dc.contributor.googleauthor | Hyun-Young Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Byung Chul Chang | - |
dc.contributor.googleauthor | Cha Yong Choi | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.identifier.doi | OAK-2005-03169 | - |
dc.contributor.localId | A00848 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A03366 | - |
dc.contributor.localId | A03430 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04421 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 15729075 | - |
dc.subject.keyword | 15729075 | - |
dc.contributor.alternativeName | Kim, Il Kwon | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Lim, Sang Hyun | - |
dc.contributor.alternativeName | Chang, Byung Chul | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Hong, You Sun | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.citation.volume | 241 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 506 | - |
dc.citation.endPage | 515 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.241(3) : 506-515, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40325 | - |
dc.type.rims | ART | - |
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