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Small-diameter blood vessels engineered with bone marrow-derived cells

DC FieldValueLanguage
dc.contributor.author김일권-
dc.contributor.author유경종-
dc.contributor.author임상현-
dc.contributor.author장병철-
dc.contributor.author장양수-
dc.contributor.author홍유선-
dc.contributor.author황기철-
dc.date.accessioned2017-05-04T07:37:17Z-
dc.date.available2017-05-04T07:37:17Z-
dc.date.issued2005-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147551-
dc.description.abstractOBJECTIVE: The objective of this study is to investigate if bone marrow-derived cells (BMCs) regenerate vascular tissues and improve patency in tissue-engineered small-diameter (internal diameter = 3 mm) vascular grafts. SUMMARY BACKGROUND DATA: BMCs have demonstrated the ability to differentiate into endothelial-like cells and vascular smooth muscle-like cells and may offer an alternative cell source for vascular tissue engineering. Thus, we tissue-engineered small-diameter vascular grafts with BMCs and decellularized arteries. METHODS: Canine BMCs were differentiated in vitro into smooth muscle alpha-actin/smooth muscle myosin heavy-chain-positive cells and von Willebrand factor/CD31-positive cells and seeded onto decellularized canine carotid arteries (internal diameter = 3 mm). The seeded grafts were implanted in cell donor dogs. The vascular-tissue regeneration and graft patency were investigated with immunohistochemistry and angiography, respectively. RESULTS: The vascular grafts seeded with BMCs remained patent for up to 8 weeks in the canine carotid artery interposition model, whereas nonseeded grafts occluded within 2 weeks. Within 8 weeks after implantation, the vascular grafts showed regeneration of the 3 elements of artery (endothelium, media, and adventitia). BMCs labeled with a fluorescent dye prior to implantation were detected in the retrieved vascular grafts, indicating that the BMCs participated in the vascular tissue regeneration. CONCLUSIONS: Here we show that BMCs have the potential to regenerate vascular tissues and improve patency in tissue-engineered small-diameter vascular grafts. This is the first report of a small-diameter neovessel engineered with BMCs as a cell source.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBone Marrow Cells*/cytology-
dc.subject.MESHBone Marrow Cells*/physiology-
dc.subject.MESHCarotid Arteries/physiology-
dc.subject.MESHCarotid Arteries/transplantation*-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDogs-
dc.subject.MESHEndothelium, Vascular/cytology*-
dc.subject.MESHGraft Survival-
dc.subject.MESHMuscle, Smooth, Vascular/cytology*-
dc.subject.MESHRegeneration-
dc.subject.MESHTissue Engineering*-
dc.subject.MESHVascular Patency-
dc.titleSmall-diameter blood vessels engineered with bone marrow-derived cells-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorSeung-Woo Cho-
dc.contributor.googleauthorSang Hyun Lim-
dc.contributor.googleauthorIl-Kwon Kim-
dc.contributor.googleauthorYoo Sun Hong-
dc.contributor.googleauthorSang-Soo Kim-
dc.contributor.googleauthorKyung Jong Yoo-
dc.contributor.googleauthorHyun-Young Park-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorByung Chul Chang-
dc.contributor.googleauthorCha Yong Choi-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorByung-Soo Kim-
dc.identifier.doiOAK-2005-03169-
dc.contributor.localIdA00848-
dc.contributor.localIdA02453-
dc.contributor.localIdA03366-
dc.contributor.localIdA03430-
dc.contributor.localIdA03448-
dc.contributor.localIdA04421-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid15729075-
dc.subject.keyword15729075-
dc.contributor.alternativeNameKim, Il Kwon-
dc.contributor.alternativeNameYoo, Kyung Jong-
dc.contributor.alternativeNameLim, Sang Hyun-
dc.contributor.alternativeNameChang, Byung Chul-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameHong, You Sun-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.citation.volume241-
dc.citation.number3-
dc.citation.startPage506-
dc.citation.endPage515-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.241(3) : 506-515, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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