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신장 이식 후 초기에 투여한 골다공증 치료제의 효과

Other Titles
 Effects of Early Administration of Vitamin D or Alendronate on the Change of Bone Mineral Density after Renal Transplantation 
 권기환  ;  김명수  ;  임재현  ;  허규하  ;  김현정  ;  안형준  ;  전경옥  ;  차봉수  ;  김순일  ;  김유선 
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.19(1) : 27-35, 2005 
Journal Title
 Journal of the Korean Society for Transplantation (대한이식학회지) 
Issue Date
Renal transplantation ; Bone mineral density ; Vitamin D ; Alendronate
Purpose: The decrease in bone mineral density (BMD) is a major complication after kidney transplantation. This was reported to occur preferentially during the first 6 months. However, the treatment and prevention strategies against a decline of BMD are not yet clear. Methods: The data on the pre-transplant baseline and post-transplant 1 year BMD were archived and retrieved in 125 renal transplant recipients. The post-transplant changes of the BMD were compared by the baseline status of the BMD and the types of anti-osteoporosis treatment either with a vitamin D agent (alfacalcidiol) (n=18) or alendronate (n=21). Anti-osteoporosis treatment began within 30 days after transplantation, with an oral administration of 0.5 mcg/day vitamin D or 70 mg/week alendronate, and maintained until 1 year after transplantation. Results: Regardless the degree of baseline BMD status, each group (the control, vitamin D, or alendronate group) showed a significant and uniform decrease of BMD during the post-transplant 1 year. The mean change in the spine BMD in the control, vitamin D, and alendronate group was -7.1±7.5%, -3.3±7.4% and -2.6±6.5%, respectively. The femur BMD also changed -5.1±7.7%, 1.1±5.3% and -1.5±8.2%, respectively. The degree of BMD decrease in the treatment groups was significantly lower than that in the control (P=0.014 in spine, P=0.003 in femur). When the severely reduced baseline BMD (T-score of spine or femur ≤-1) subgroups were analysed separately, the treatment groups (-3.7±6.5% in vitamin D and -1.1±6.4% in alendronate group) showed a significantly less decrease in the spine BMD than the control (-8.2±6.2%)(P=0.036). The femur BMD also showed a less decrease in the BMD in the treatment group, but this was not statistically significant (P=0.234). There was no significant difference between the vitamin D and alendronate treatment groups. Conclusion: After renal transplantation, early administration of vitamin D or alendronate showed some benefit to reduce the post-transplant decrease of BMD in both spine and femur area.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ki Hwan(권기환)
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Ahn, Hyung Joon(안형준)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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