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Variable patterns of positron emission tomography in the assessment of patients with extramammary Paget's disease

Authors
 Sung Bin Cho  ;  Mijin Yun  ;  Min-Geol Lee  ;  Kee Yang Chung 
Citation
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.52(2) : 353-355, 2005 
Journal Title
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 
ISSN
 0190-9622 
Issue Date
2005
MeSH
Aged ; Bone Neoplasms/diagnostic imaging* ; Bone Neoplasms/secondary* ; Fatal Outcome ; Fluorodeoxyglucose F18 ; Genital Neoplasms, Male/diagnostic imaging* ; Genital Neoplasms, Male/pathology ; Humans ; Lymphatic Metastasis/diagnostic imaging* ; Male ; Middle Aged ; Neoplasm Staging ; Paget Disease, Extramammary/diagnostic imaging* ; Paget Disease, Extramammary/pathology ; Paget Disease, Extramammary/secondary* ; Positron-Emission Tomography* ; Radiopharmaceuticals ; Scrotum/diagnostic imaging* ; Scrotum/pathology ; Sepsis/complications
Keywords
15692486
Abstract
Whole body 18F-fluorodeoxyglucose (FDG) positron emission tomography was performed for staging in 7 extramammary Paget's disease patients and 4 tests showed mild FDG uptake at the primary sites. Histologically, all 4 tumors were found to be thicker than 2 cm. Among the 4 patients, 2 showed multiple hypermetabolic foci of skeletal metastasis and lymph node involvement. Extramammary Paget's disease (EMPD) is a heterogenous condition representing either an intraepithelial adenocarcinoma in situ with potential to become invasive, or pagetoid spread of an underlying adnexal tumor or a regional internal malignancy.1 A thorough general physical examination, along with laboratory and radiographic testing, with emphasis on the region adjacent to the site of EMPD is indicated when genitalia or perianal skin are involved, as they may be associated with underlying neoplasms of the genitourinary or gastrointestinal tracts. Between May 2000 and July 2004, whole body 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) was performed for staging in 7 EMPD patients. All 7 were male and mean age was 63.9 years with age ranging from 55 to 75 years. Location, size, and thickness of the tumor are summarized in Table I. Other imaging studies, including gastrointestinal endoscopy, intravenous pyelogram, and abdominopelvic ultrasonography were performed and did not show remarkable findings in any of the 7 patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0190962204036369
DOI
10.1016/j.jaad.2004.10.864
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147404
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