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Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice

Authors
 Seong Hwan Kim  ;  Kyoung Ok Hong  ;  Jae Kwan Hwang  ;  Kwang-Kyun Park 
Citation
 FOOD AND CHEMICAL TOXICOLOGY, Vol.43(1) : 117-122, 2005 
Journal Title
 FOOD AND CHEMICAL TOXICOLOGY 
ISSN
 0278-6915 
Issue Date
2005
MeSH
Animals ; Antineoplastic Agents/adverse effects* ; Antineoplastic Agents/therapeutic use ; Blood Urea Nitrogen ; Cisplatin/adverse effects* ; Cisplatin/therapeutic use ; Creatinine/blood ; Curcumin/pharmacology ; Kidney/drug effects* ; Kidney/metabolism ; Male ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred ICR ; Organ Size/drug effects ; Phenols/pharmacology* ; Random Allocation ; Transcription Factors/metabolism* ; Transcription, Genetic
Keywords
Xanthorrhizol ; Cisplatin ; Nephrotoxicity ; Transcription factors
Abstract
Cisplatin is a widely used anticancer drug, but it can produce undesirable side effects such as nephrotoxicity. The present study investigated the effect of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) on cisplatin-induced nephrotoxicity in mice. A single dose of cisplatin (45 mg/kg, i.p.) significantly elevated the levels of blood urea nitrogen, serum creatinine, and the kidney to body weight ratio, but the pretreatment of xanthorrhizol (200 mg/kg/day, per os) for 4 days significantly attenuated the cisplatin-induced nephrotoxicity. The preventive effect of xanthorrhizol was more efficacious than that of curcumin with the same amount (200 mg/kg). However, this effect seemed not to be related with the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors such as nuclear factor-kappaB (NF-κB) and activator protein 1 (AP-1). This is first time the preventive effect of xanthorrhizol on cisplatin-induced nephrotoxicity has been demonstrated, and these data suggest that the administration of xanthorrhizol is a promising approach in the treatment of nephrotoxicity caused by cisplatin.
Full Text
http://www.sciencedirect.com/science/article/pii/S0278691504002820
DOI
10.1016/j.fct.2004.08.018
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147341
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