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Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells

Authors
 Kyung-Su Kim  ;  Kwang-Hyeon Rhee  ;  Joo-Heon Yoon  ;  Jeung Gweon Lee  ;  Joo-Hwan Lee  ;  Jong-Bum Yoo 
Citation
 ORAL ONCOLOGY, Vol.41(4) : 383-389, 2005 
Journal Title
 ORAL ONCOLOGY 
ISSN
 1368-8375 
Issue Date
2005
MeSH
Apoptosis*/drug effects ; Caspase 3 ; Caspase Inhibitors ; Caspases/metabolism* ; Cell Proliferation ; DNA Fragmentation ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Enzyme Inhibitors/pharmacology ; Ginkgo biloba ; Humans ; Mouth Neoplasms/enzymology ; Mouth Neoplasms/pathology* ; Phytotherapy* ; Plant Extracts/antagonists & inhibitors ; Plant Extracts/pharmacology* ; Tumor Cells, Cultured
Keywords
Ginkgo biloba extract ; Oral cavity cancer ; Apoptosis ; Caspase-3
Abstract
We have investigated whether Ginkgo biloba extract (EGb 761) induces apoptosis of oral cavity cancer cells and attempted to characterize the apoptotic pathway activated by EGb 761. The inhibition of SCC 1483 oral cavity cancer cells proliferation was noted from 250 μg/ml of EGb 761. Apoptosis was observed after 24 h of incubation with 250 μg/ml EGb 761 and occurred in a time- and dose-dependent manner. Apoptosis was confirmed by DNA fragmentation and PARP cleavage. Co-treatment with the caspase inhibitor (z-VAD-fmk) inhibited apoptosis and PARP cleavage induced by EGb 761. Caspase-3 activity was upregulated by EGb 761 but reduced to the control level by co-treating with z-VAD-fmk. In summary, EGb 761 induces apoptosis of oral cavity cancer cells and caspase-3 is activated in this apoptosis. Therefore, EGb 761 may be considered as a possible chemopreventive agent against oral cavity cancer.
Full Text
http://www.sciencedirect.com/science/article/pii/S1368837504002313
DOI
10.1016/j.oraloncology.2004.09.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoo, Jong Bum(유종범)
Yoon, Joo Heon(윤주헌)
Lee, Jeung Gweon(이정권)
Lee, Joo Hwan(이주환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147337
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