Cited 66 times in
Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 유종범 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이정권 | - |
dc.contributor.author | 이주환 | - |
dc.date.accessioned | 2017-05-04T07:28:19Z | - |
dc.date.available | 2017-05-04T07:28:19Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147337 | - |
dc.description.abstract | We have investigated whether Ginkgo biloba extract (EGb 761) induces apoptosis of oral cavity cancer cells and attempted to characterize the apoptotic pathway activated by EGb 761. The inhibition of SCC 1483 oral cavity cancer cells proliferation was noted from 250 μg/ml of EGb 761. Apoptosis was observed after 24 h of incubation with 250 μg/ml EGb 761 and occurred in a time- and dose-dependent manner. Apoptosis was confirmed by DNA fragmentation and PARP cleavage. Co-treatment with the caspase inhibitor (z-VAD-fmk) inhibited apoptosis and PARP cleavage induced by EGb 761. Caspase-3 activity was upregulated by EGb 761 but reduced to the control level by co-treating with z-VAD-fmk. In summary, EGb 761 induces apoptosis of oral cavity cancer cells and caspase-3 is activated in this apoptosis. Therefore, EGb 761 may be considered as a possible chemopreventive agent against oral cavity cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | ORAL ONCOLOGY | - |
dc.publisher | ORAL ONCOLOGY | - |
dc.relation.isPartOf | ORAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis*/drug effects | - |
dc.subject.MESH | Caspase 3 | - |
dc.subject.MESH | Caspase Inhibitors | - |
dc.subject.MESH | Caspases/metabolism* | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | DNA Fragmentation | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Ginkgo biloba | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mouth Neoplasms/enzymology | - |
dc.subject.MESH | Mouth Neoplasms/pathology* | - |
dc.subject.MESH | Phytotherapy* | - |
dc.subject.MESH | Plant Extracts/antagonists & inhibitors | - |
dc.subject.MESH | Plant Extracts/pharmacology* | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.contributor.googleauthor | Kwang-Hyeon Rhee | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Jeung Gweon Lee | - |
dc.contributor.googleauthor | Joo-Hwan Lee | - |
dc.contributor.googleauthor | Jong-Bum Yoo | - |
dc.identifier.doi | 10.1016/j.oraloncology.2004.09.013 | - |
dc.contributor.localId | A00298 | - |
dc.contributor.localId | A02510 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A03095 | - |
dc.contributor.localId | A03170 | - |
dc.relation.journalcode | J02440 | - |
dc.identifier.eissn | 1879-0593 | - |
dc.identifier.pmid | 15792610 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1368837504002313 | - |
dc.subject.keyword | Ginkgo biloba extract | - |
dc.subject.keyword | Oral cavity cancer | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Caspase-3 | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Yoo, Jong Bum | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.contributor.alternativeName | Lee, Joo Hwan | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 383 | - |
dc.citation.endPage | 389 | - |
dc.identifier.bibliographicCitation | ORAL ONCOLOGY, Vol.41(4) : 383-389, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48509 | - |
dc.type.rims | ART | - |
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