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LDL 콜레스테롤 유전율과 유전자 분리모형 연구

Other Titles
 Heritability and Segregation Analysis of the Level of LDL-Cholesterol 
Authors
 지선하  ;  윤지은  ;  남정모  ;  서일 
Citation
 KOREAN CIRCULATION JOURNAL, Vol.35(3) : 233-239, 2005 
Journal Title
 KOREAN CIRCULATION JOURNAL 
ISSN
 1738-5520 
Issue Date
2005
MeSH
LDL cholesterol;Heritability;Segregation
Keywords
LDL cholesterol;Heritability;Segregation
Abstract
Background and Objectives:The purpose of this study was to investigate the familial correlation and heritability of the LDL cholesterol level through a segregation analysis. Subjects and Methods:This study was based on the data from 9,884 Korean individuals, ascertained as pedigrees, who had participated in the 1998 and 2001 Korean National Health & Nutrition Examination Survey. The subjects of the segregation analysis were 3,613 Korean with more than five family members. Results:The LDL cholesterol level revealed a strong familial correlation among spouses, parental-offspring and siblings; a low correlation with spouses, but a high correlation with parental-offspring and siblings. The heritability of the LDL cholesterol level was 37.3%, when controlled for age, age2, gender, age×gender, waist circumference, smoking, alcohol drinking, exercise and education. After the segregation analysis, models of the major gene effects were rejected in the general population. However, the Mendelian dominant and co-dominant models were found in high risk families. Conclusion:In conclusion, the randomly ascertained Korean families of this study showed strong familial aggregation in the LDL cholesterol level. This suggested that variations in the level of LDL cholesterol may be influenced by a major gene effect.
Files in This Item:
T200500063.pdf Download
DOI
OAK-2005-02469
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147322
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