Cited 0 times in
LDL 콜레스테롤 유전율과 유전자 분리모형 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남정모 | - |
dc.contributor.author | 서일 | - |
dc.contributor.author | 윤지은 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2017-05-04T07:27:43Z | - |
dc.date.available | 2017-05-04T07:27:43Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147322 | - |
dc.description.abstract | Background and Objectives:The purpose of this study was to investigate the familial correlation and heritability of the LDL cholesterol level through a segregation analysis. Subjects and Methods:This study was based on the data from 9,884 Korean individuals, ascertained as pedigrees, who had participated in the 1998 and 2001 Korean National Health & Nutrition Examination Survey. The subjects of the segregation analysis were 3,613 Korean with more than five family members. Results:The LDL cholesterol level revealed a strong familial correlation among spouses, parental-offspring and siblings; a low correlation with spouses, but a high correlation with parental-offspring and siblings. The heritability of the LDL cholesterol level was 37.3%, when controlled for age, age2, gender, age×gender, waist circumference, smoking, alcohol drinking, exercise and education. After the segregation analysis, models of the major gene effects were rejected in the general population. However, the Mendelian dominant and co-dominant models were found in high risk families. Conclusion:In conclusion, the randomly ascertained Korean families of this study showed strong familial aggregation in the LDL cholesterol level. This suggested that variations in the level of LDL cholesterol may be influenced by a major gene effect. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 233~239 | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | LDL cholesterol;Heritability;Segregation | - |
dc.title | LDL 콜레스테롤 유전율과 유전자 분리모형 연구 | - |
dc.title.alternative | Heritability and Segregation Analysis of the Level of LDL-Cholesterol | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | 지선하 | - |
dc.contributor.googleauthor | 윤지은 | - |
dc.contributor.googleauthor | 남정모 | - |
dc.contributor.googleauthor | 서일 | - |
dc.identifier.doi | OAK-2005-02469 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01899 | - |
dc.contributor.localId | A02608 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.relation.journalsince | 2005~ | - |
dc.relation.journalbefore | ~2004 Korean Circulation Journal (순환기) | - |
dc.subject.keyword | LDL cholesterol;Heritability;Segregation | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Suh, Il | - |
dc.contributor.alternativeName | Yun, Ji Eun | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 233 | - |
dc.citation.endPage | 239 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.35(3) : 233-239, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48494 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.