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The Haemodynamic Effects of Propranolol and Atenolol Medication on Dobutamine Infusion in Patients with Coronary Artery Obstructive Disease

 YJ OH  ;  JH LEE  ;  JY KIM  ;  JW SONG  ;  YW HONG  ;  YL KWAK 
 Journal of International Medical Research, Vol.33(3) : 329-336, 2005 
Journal Title
 Journal of International Medical Research 
Issue Date
Adrenergic beta-Antagonists/pharmacology ; Aged ; Arteries ; Atenolol/pharmacology* ; Coronary Artery Bypass/methods ; Coronary Artery Disease/drug therapy* ; Dobutamine/administration & dosage* ; Dobutamine/pharmacology ; Dose-Response Relationship, Drug ; Female ; Heart Rate ; Hemodynamics ; Humans ; Male ; Middle Aged ; Propranolol/pharmacology* ; Time Factors
Atenolol ; Propranolol ; Dobutamine ; Coronary artery obstructive disease
We compared the haemodynamic effects of beta-blockers on dobutamine infusion in 60 patients undergoing coronary artery bypass graft surgery. All patients had been taking propranolol (n = 30) or atenolol (n = 30) pre-operatively for at least 1 month. After sternotomy, dobutamine was infused at 2 microg/kg per min, and the dose increased to 4 microg/kg per min and then 8 microg/kg per min, at 15-min intervals. In both groups, dobutamine infusion did not increase the cardiac index or the heart rate, but was associated with an increase in mean arterial pressure, systemic vascular resistance index and mean pulmonary arterial pressure in a dose-dependent manner. The haemodynamic responses to dobutamine infusion were similar in the two groups. We conclude that pre-operative medication with beta-blockers reduced the inotropic and chronotropic effects of dobutamine infusion. There was no difference between the modification produced by propranolol, a non-selective beta-blocker, and that produced by atenolol, a selective beta1-blocker, however.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Ji Young(김지영) ORCID logo https://orcid.org/0000-0001-5822-0338
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Jong Wha(이종화)
Hong, Yong Woo(홍용우)
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