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ArtecollⓇ과 RestylaneⓇ의 성대내 주입술 후 조직학적 변화 및 성대점막 진동 양상 : 생체 동물 실험

Other Titles
 Histology and Stroboscopic Findings after Injection of ArtecollⓇ and RestylaneⓇ into Paralyzed Canine Vocal Fold:in vivo Canine Study 
 임재열  ;  김한수  ;  김영호  ;  권순호  ;  장정현  ;  이윤재  ;  김현경  ;  최홍식 
 Korean Journal of Otolaryngology (대한이비인후과학회지), Vol.48(6) : 754-759, 2005 
Journal Title
 Korean Journal of Otolaryngology (대한이비인후과학회지) 
Issue Date
Artecoll ; Restylane ; Injection laryngoplasty ; Stroboscopy ; Histopathology ; Canine study
Artecoll ; Restylane ; Injection laryngoplasty ; Stroboscopy ; Histopathology ; Canine study
Background and Objectives:The aims of this study are to introduce Artecoll and Restaylane, that have been available for facial augmentation, as new materials for injection laryngoplasty, to investigate the mucosal wave of true vocal folds after the injection of these two materials into the true vocal fold, and to assess its biocompatibility and durability. Subjects and Method:After complete paralysisof the right recurrent laryngeal nerve of 6 Beagle dogs, the dogs were divided into the Artecoll injection group and the Restylane injection group, and Artecoll or Restylane was injected into vocalis muscle and vocal ligament. The recurrent laryngeal nerve of the opposite side was stimulated, the posterior commissure was sutured, and the mucosal wave of true vocal folds was examined by stroboscopy in in vivo canine study 1, 3, and 6 months after the injection. And, histopathological change of the injected materials after total laryngectomy wasexamined by hematoxylin and eosin (H & E) staining and masson trichrome staining. Results:In both the Artecoll injection and the Restylane injection groups, the mucosal wave of true vocal folds was detected by stroboscopic examination until 6 months after the injection, and the difference of the mucosal wave of true vocal folds between these two groups was difficult to detect. Histological studies revealed that the injected materials remained in the vocal ligament and vocalis muscle and theses two materials were resorbed with time, Artecoll showing less resorption. These two materials were biocompatible and, particularly, Restylane showed less foreign body reaction. Conclusion:Since both Artecoll and Restylane are biocompatible and durable, they areconsidered as the suitable material for injection larygoplasty, and additional long-term studies are required.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Ho(김영호)
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Hong Shik(최홍식)
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