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Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: results from the Korean Nosocomial Infections Surveillance System (KONIS).

Authors
 J.Y. Choi  ;  Y.G. Kwak  ;  H. Yoo  ;  S.-O. Lee  ;  H.B. Kim  ;  S.H. Han  ;  H.J. Choi  ;  H.Y. Kim  ;  S.R. Kim  ;  T.H. Kim  ;  H. Lee  ;  H.K. Chun  ;  J.-S. Kim  ;  B.W. Eun  ;  D.W. Kim  ;  H.-S. Koo  ;  E.-H. Cho  ;  K. Lee  ;  Korean Nosocomial Infections Surveillance System (KONIS) 
Citation
 JOURNAL OF HOSPITAL INFECTION, Vol.92(4) : 363-371, 2016 
Journal Title
 JOURNAL OF HOSPITAL INFECTION 
ISSN
 0195-6701 
Issue Date
2016
MeSH
Candidiasis/epidemiology ; Catheter-Related Infections/epidemiology* ; Catheter-Related Infections/microbiology ; Cross Infection/epidemiology* ; Cross Infection/microbiology ; Drug Resistance, Bacterial* ; Epidemiological Monitoring* ; Gram-Negative Bacteria/drug effects* ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/epidemiology ; Gram-Negative Bacterial Infections/microbiology ; Gram-Positive Bacteria/drug effects* ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Intensive Care Units ; Pneumonia, Ventilator-Associated/epidemiology* ; Pneumonia, Ventilator-Associated/microbiology ; Republic of Korea/epidemiology
Keywords
Device-associated infections ; Healthcare-associated infection ; Pathogen ; Resistance ; Surveillance
Abstract
BACKGROUND: For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. AIM: To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. METHODS: Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. FINDINGS: The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6% to 32.6% and from 52.8% to 73.5%, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6% to 49.2% for CLABSI, and from 44.3% to 23.8% for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95% to 90.2% (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8% to 14.7% and from 15.0% to 1.8%, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9% to 89.8% (P < 0.001). CONCLUSION: The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria.
Full Text
http://www.sciencedirect.com/science/article/pii/S0195670116000049
DOI
10.1016/j.jhin.2015.12.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147209
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