0 286

Cited 4 times in

Meibomian gland dysfunction and tear cytokines after cataract surgery according to preoperative meibomian gland status.

Authors
 Ji Won Jung  ;  Soo Jung Han  ;  Sang Min Nam  ;  Tae-im Kim  ;  Eung Kweon Kim  ;  Kyoung Yul Seo 
Citation
 CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.44(7) : 555-562, 2016 
Journal Title
 CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 
ISSN
 1442-6404 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Cytokines/metabolism* ; Eye Proteins/metabolism* ; Eyelid Diseases/etiology* ; Eyelid Diseases/metabolism ; Female ; Humans ; Immunoassay/methods ; Lens Implantation, Intraocular ; Male ; Meibomian Glands/metabolism ; Meibomian Glands/pathology* ; Middle Aged ; Phacoemulsification/adverse effects* ; Preoperative Period ; Prospective Studies ; Tears/metabolism*
Keywords
cataract surgery ; interleukin-6 ; meibomian gland dysfunction ; tear cytokine
Abstract
BACKGROUND: To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), we evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade. DESIGN: Prospective, observational case series. PARTICIPANTS: A total of 50 eyes from 50 patients who underwent cataract surgery were included. METHODS: Patients were classified into two groups: Group I had no or minimal MGD, and group II had grades 2-4 MGD. Ocular surface parameters were measured, including tear film break-up time, Schirmer I test, ocular surface staining and Ocular Surface Disease Index, and tear cytokine levels were measured. MAIN OUTCOME MEASURES: The main outcomes were changes in ocular surface parameters and inflammatory tear cytokine concentrations. RESULTS: In group II, preoperative MGD grade, ocular surface staining, tear film break-up time and Ocular Surface Disease Index were worse, and mean interleukin (IL)-2, IL-6 and TNF-α levels were higher than those of group I. MGD and ocular surface parameters were worsened to a greater degree after surgery in group II than in group I (P < 0.050). In group II, IL-6 and TNF-α levels significantly increased at postoperative 1 month, and there were significant correlations between changes in ocular surface parameters and tear cytokines (IL-2, IL-6 and TNF-α; P < 0.050). CONCLUSIONS: The extent to which the MGD grade was aggravated following cataract surgery differed based on preoperative MGD grade. Preoperative MGD and ocular surface status should be carefully evaluated.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ceo.12744/abstract
DOI
10.1111/ceo.12744
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147177
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse