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Lowest Oxyhemoglobin Saturation May Be an Independent Factor Influencing Auditory Function in Severe Obstructive Sleep Apnea.

 Young Joon Seo  ;  Sang Yoo Park  ;  Hyo Jin Chung  ;  Chang-Hoon Kim  ;  Jeung-Gweon Lee  ;  Sung Huhn Kim  ;  Hyung-Ju Cho 
 Journal of Clinical Sleep Medicine, Vol.12(5) : 653-658, 2016 
Journal Title
 Journal of Clinical Sleep Medicine 
Issue Date
Female ; Hearing Disorders/complications* ; Hearing Disorders/metabolism* ; Humans ; Male ; Middle Aged ; Oxyhemoglobins/metabolism* ; Polysomnography ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Sleep Apnea, Obstructive/complications* ; Sleep Apnea, Obstructive/metabolism*
obstructive sleep apnea ; oxyhemoglobin saturation ; polysomnography ; sensorineural hearing loss
STUDY OBJECTIVES: The aims of this study were to determine if a correlation exists between the level of hypoxia induced by severe obstructive sleep apnea syndrome (OSAS) and the level of auditory dysfunction when verifying such a relationship using polysomnography (PSG). METHODS: A retrospective review of 41 patients with severe OSAS was performed. Independent risk factors for hearing impairment included parameters of PSG, which were analyzed in two hearing groups at a level ≥ 40 decibels (dB). RESULTS: Oxyhemoglobin saturation, especially the lowest oxyhemoglobin saturation level, showed lower thresholds in the hearing impairment group than in the control group (p = 0.039 at NREM stage; p = 0.029 at REM stage; p = 0.001 at total sleep stage). After adjusting for other risk factors, the sole variable that remained significant was lowest oxyhemoglobin saturation (total; p = 0.046). In the correlation analysis, a decreasing lowest oxyhemoglobin saturation (from all subjects, n = 41) correlated with a greater mean hearing threshold (R(2) = 0.297; p < 0.001). CONCLUSION: Our results indicated that lowest oxyhemoglobin saturation in PSG is the only variable correlated with the hearing threshold. This finding could be predictive of possible hearing alternation in patients with severe OSAS. COMMENTARY: A commentary on this article appears in this issue on page 641.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Chung, Hyo Jin(정효진)
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
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