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Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients With Immunoglobulin A Nephropathy.

Authors
 H.S. Jeong  ;  J. Lee  ;  B.J. Lim  ;  H.J. Kwon  ;  Y.S. Kim  ;  B.S. Kim  ;  K.H. Huh  ;  S.I. Kim  ;  M.S. Kim  ;  H.J. Jeong 
Citation
 Transplantation Proceedings, Vol.48(3) : 887-889, 2016 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2016
MeSH
Adult ; Biopsy ; Blood Glucose/metabolism* ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology* ; Female ; Follow-Up Studies ; Forecasting* ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/epidemiology ; Glomerulonephritis, IGA/surgery* ; Graft Survival ; Humans ; Incidence ; Kidney/ultrastructure ; Kidney Transplantation/adverse effects* ; Male ; Microscopy, Electron ; Postoperative Complications* ; Prevalence ; Republic of Korea/epidemiology ; Retrospective Studies ; Transplantation, Homologous
Abstract
BACKGROUND: The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases. METHODS: We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution. RESULTS: Sixteen patients (14.4%) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2%) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff "mm" scores were higher and "M1" of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up. CONCLUSIONS: Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134516001354
DOI
10.1016/j.transproceed.2015.11.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김범석(Kim, Beom Seok) ORCID logo https://orcid.org/0000-0002-5732-2583
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
이주한(Lee, Ju Han)
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정향숙(Jeong, H.S.)
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147157
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