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Clinic and Home Blood Pressure Lowering Effect of an Angiotensin Receptor Blocker, Fimasartan, in Postmenopausal Women with Hypertension.

 Song-Yi Kim  ;  Seung-Jae Joo  ;  Mi-Seung Shin  ;  Changsoo Kim  ;  Eun Joo Cho  ;  Ki-Chul Sung  ;  Seok-Min Kang  ;  Dong-Soo Kim  ;  Seung Hwan Lee  ;  Kyung-Kuk Hwang  ;  Jeong Bae Park 
 MEDICINE, Vol.95(22) : 3764, 2016 
Journal Title
Issue Date
Adult ; Aged ; Ambulatory Care Facilities/statistics & numerical data ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/therapeutic use* ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use* ; Biphenyl Compounds/adverse effects ; Biphenyl Compounds/therapeutic use* ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory/statistics & numerical data ; Female ; Hospitals, University ; Humans ; Hypertension/drug therapy* ; Middle Aged ; Postmenopause* ; Prospective Studies ; Pulse ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use* ; Republic of Korea ; Tetrazoles/adverse effects ; Tetrazoles/therapeutic use*
Angiotensin receptor blockers may be an appropriate first-line agent for postmenopausal women with hypertension because the activation of renin-angiotensin-aldosterone system is suggested as one possible mechanism of postmenopausal hypertension. However, there are few studies substantiating this effect. This study aimed to investigate clinic and home blood pressure (BP) lowering effect of fimasartan, a new angiotensin receptor blocker, in postmenopausal women with hypertension.Among patients with hypertension enrolled in K-Mets Study, 1373 women with fimasartan as a first antihypertensive drug and 3-months follow-up data were selected. They were divided into 2 groups; premenopausal women (pre-MPW; n = 382, 45.3 ± 4.6 years) and postmenopausal women (post-MPW; n = 991, 60.9 ± 8.2 years).Baseline clinic systolic BP was not different (pre-MPW; 152.9 ± 15.2 vs. post-MPW; 152.8 ± 13.5 mm Hg), but diastolic BP was lower in post-MPW (pre-MPW; 95.7 ± 9.4 vs. post-MPW; 91.9 ± 9.4 mm Hg, P <0.001). After 3-month treatment, clinic BP declined effectively without significant differences between 2 groups (Δsystolic/diastolic BP: pre-MPW; -25.7 ± 17.7/-14.2 ± 11.3 vs. post-MPW; -25.7 ± 16.3/-13.1 ± 10.9 mm Hg). Home morning and evening systolic BP decreased similarly in both groups (Δmorning/evening systolic BP: pre-MPW; -21.3 ± 17.9/-23.1 ± 15.8 vs. post-MPW; -20.4 ± 17.3/-20.2 ± 19.2 mm Hg). Fimasartan also significantly decreased the standard deviations of home morning and evening systolic BP of pre-MPW and post-MPW.Fimasartan was a similarly effective BP lowering agent in both post-MPW and pre-MPW with hypertension, and it also decreased day-to-day BP variability.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
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