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Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease.

 Changhwan Kim  ;  Ji Ye Jung  ;  Young Sam Kim  ;  Jae Seung Lee  ;  Chin Kook Rhee  ;  Jin Hwa Lee  ;  Ji-Hyun Lee  ;  Tae-Hyung Kim  ;  Seong Yong Lim  ;  Seung Soo Sheen  ;  Joon Beom Seo  ;  Yeon-Mok Oh  ;  Sang-Do Lee  ;  Yong Bum Park 
 RESPIRATION, Vol.91(5) : 351-358, 2016 
Journal Title
Issue Date
Aged ; Comorbidity ; Disease Progression ; Exercise Tolerance/physiology* ; Forced Expiratory Volume ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/physiopathology* ; Republic of Korea/epidemiology ; Smoking/epidemiology ; Vital Capacity ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood* ; Vitamin D Deficiency/epidemiology ; Walk Test
BACKGROUND: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. OBJECTIVES: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. METHODS: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ≥17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). RESULTS: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). CONCLUSION: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
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