Cited 3 times in
Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease.
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2017-02-27T08:15:24Z | - |
dc.date.available | 2017-02-27T08:15:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147132 | - |
dc.description.abstract | BACKGROUND: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. OBJECTIVES: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. METHODS: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ≥17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). RESULTS: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). CONCLUSION: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 351~358 | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Exercise Tolerance/physiology* | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/epidemiology | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/physiopathology* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Smoking/epidemiology | - |
dc.subject.MESH | Vital Capacity | - |
dc.subject.MESH | Vitamin D/analogs & derivatives | - |
dc.subject.MESH | Vitamin D/blood | - |
dc.subject.MESH | Vitamin D Deficiency/blood* | - |
dc.subject.MESH | Vitamin D Deficiency/epidemiology | - |
dc.subject.MESH | Walk Test | - |
dc.title | Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease. | - |
dc.type | Article | - |
dc.publisher.location | Switzerland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Changhwan Kim | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Chin Kook Rhee | - |
dc.contributor.googleauthor | Jin Hwa Lee | - |
dc.contributor.googleauthor | Ji-Hyun Lee | - |
dc.contributor.googleauthor | Tae-Hyung Kim | - |
dc.contributor.googleauthor | Seong Yong Lim | - |
dc.contributor.googleauthor | Seung Soo Sheen | - |
dc.contributor.googleauthor | Joon Beom Seo | - |
dc.contributor.googleauthor | Yeon-Mok Oh | - |
dc.contributor.googleauthor | Sang-Do Lee | - |
dc.contributor.googleauthor | Yong Bum Park | - |
dc.identifier.doi | 10.1159/000445266 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J02613 | - |
dc.identifier.eissn | 1423-0356 | - |
dc.identifier.pmid | 27105006 | - |
dc.identifier.url | https://www.karger.com/Article/Pdf/445266 | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.citation.volume | 91 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 358 | - |
dc.identifier.bibliographicCitation | RESPIRATION, Vol.91(5) : 351-358, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47163 | - |
dc.type.rims | ART | - |
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