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No effect of tumor-infiltrating lymphocytes (TILs) on prognosis in patients with early triple-negative breast cancer: Validation of recommendations by the International TILs Working Group 2014.

Authors
 HYUNG SEOK PARK  ;  ILYEONG HEO  ;  JEE YE KIM  ;  SANGHWA KIM  ;  SANGGEUN NAM  ;  SEHO PARK  ;  SEUNG IL KIM 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.114(1) : 17-21, 2016 
Journal Title
 JOURNAL OF SURGICAL ONCOLOGY 
ISSN
 0022-4790 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism* ; Chemotherapy, Adjuvant ; Female ; Follow-Up Studies ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism* ; Mastectomy ; Middle Aged ; Neoplasm Staging ; Practice Guidelines as Topic ; Prognosis ; Retrospective Studies ; Survival Analysis ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/mortality* ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/therapy
Keywords
TILs ; biomarkers ; breast ; lymphocytic infiltration ; neoplasms ; prognosis ; survival
Abstract
PURPOSE: The aim of this study was to examine the International TILs Working Group 2014 (IWG) recommendations for evaluating the clinical utility of tumor-infiltrating lymphocytes (TILs) in patients with early triple-negative breast cancer (TNBC). METHODS: Records for 133 patients with early TNBC who underwent surgery between 2008 and 2010 were reviewed. A total of 121 of 133 formalin-fixed, paraffin-embedded tumor samples were available and reviewed following IWG recommendations. RESULTS: Most of the patients had node-negative T1-2 tumors and received adjuvant chemotherapy; T1-2 tumors accounted for 117 of 121 cases. Sixty-two percent (75/121) of all patients had >10% stromal TILs. Intratumoral TILs and lymphocyte-predominant breast cancer (LPBC) were observed in 72% and 19% of the patients, respectively. However, there were no significant differences according to the presence of stromal TILs, intratumoral TILs, TILs at the invasive edge, or LPBC in terms of recurrence-free and overall survival (all P > 0.05). A multivariate analysis adjusted for T and N stage, grade, and adjuvant chemotherapy revealed that no TILs parameters were associated with survival outcomes. CONCLUSIONS: TILs evaluations following the IWG recommendations may not be useful for predicting survival outcomes in patients with early TNBC.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.24275/abstract
DOI
10.1002/jso.24275
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147075
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