Cited 13 times in
No effect of tumor-infiltrating lymphocytes (TILs) on prognosis in patients with early triple-negative breast cancer: Validation of recommendations by the International TILs Working Group 2014.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승일 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 박형석 | - |
dc.date.accessioned | 2017-02-27T08:05:20Z | - |
dc.date.available | 2017-02-27T08:05:20Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147075 | - |
dc.description.abstract | PURPOSE: The aim of this study was to examine the International TILs Working Group 2014 (IWG) recommendations for evaluating the clinical utility of tumor-infiltrating lymphocytes (TILs) in patients with early triple-negative breast cancer (TNBC). METHODS: Records for 133 patients with early TNBC who underwent surgery between 2008 and 2010 were reviewed. A total of 121 of 133 formalin-fixed, paraffin-embedded tumor samples were available and reviewed following IWG recommendations. RESULTS: Most of the patients had node-negative T1-2 tumors and received adjuvant chemotherapy; T1-2 tumors accounted for 117 of 121 cases. Sixty-two percent (75/121) of all patients had >10% stromal TILs. Intratumoral TILs and lymphocyte-predominant breast cancer (LPBC) were observed in 72% and 19% of the patients, respectively. However, there were no significant differences according to the presence of stromal TILs, intratumoral TILs, TILs at the invasive edge, or LPBC in terms of recurrence-free and overall survival (all P > 0.05). A multivariate analysis adjusted for T and N stage, grade, and adjuvant chemotherapy revealed that no TILs parameters were associated with survival outcomes. CONCLUSIONS: TILs evaluations following the IWG recommendations may not be useful for predicting survival outcomes in patients with early TNBC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 17~21 | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating/metabolism* | - |
dc.subject.MESH | Mastectomy | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Practice Guidelines as Topic | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/immunology | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/mortality* | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/pathology | - |
dc.subject.MESH | Triple Negative Breast Neoplasms/therapy | - |
dc.title | No effect of tumor-infiltrating lymphocytes (TILs) on prognosis in patients with early triple-negative breast cancer: Validation of recommendations by the International TILs Working Group 2014. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | HYUNG SEOK PARK | - |
dc.contributor.googleauthor | ILYEONG HEO | - |
dc.contributor.googleauthor | JEE YE KIM | - |
dc.contributor.googleauthor | SANGHWA KIM | - |
dc.contributor.googleauthor | SANGGEUN NAM | - |
dc.contributor.googleauthor | SEHO PARK | - |
dc.contributor.googleauthor | SEUNG IL KIM | - |
dc.identifier.doi | 10.1002/jso.24275 | - |
dc.contributor.localId | A00658 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A01753 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 27157771 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.24275/abstract | - |
dc.subject.keyword | TILs | - |
dc.subject.keyword | biomarkers | - |
dc.subject.keyword | breast | - |
dc.subject.keyword | lymphocytic infiltration | - |
dc.subject.keyword | neoplasms | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Kim, Seung Il | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Kim, Seung Il | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.citation.volume | 114 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 21 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.114(1) : 17-21, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47107 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.