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Clinical predictors of silent but substantial liver fibrosis in primary Sjogren's syndrome.

 Sang-Won Lee  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Jungsik Song  ;  Yong-Beom Park  ;  Soo-Kon Lee  ;  Kwang-Hyub Han  ;  Seung Up Kim 
 MODERN RHEUMATOLOGY, Vol.26(4) : 576-582, 2016 
Journal Title
Issue Date
Adult ; Asymptomatic Diseases/epidemiology ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Liver/diagnostic imaging* ; Liver Cirrhosis*/diagnosis ; Liver Cirrhosis*/epidemiology ; Liver Cirrhosis*/etiology ; Liver Cirrhosis*/physiopathology ; Liver Function Tests/methods ; Male ; Middle Aged ; Patient Acuity ; Predictive Value of Tests ; Prevalence ; Republic of Korea/epidemiology ; Sjogren's Syndrome*/complications ; Sjogren's Syndrome*/diagnosis ; Ultrasonography/methods
Liver fibrosis ; Sjögren's syndrome ; Transient elastography
OBJECTIVES: To investigate the prevalence and the predictors of silent but substantial liver fibrosis in patients with primary Sjogren's syndrome (pSS). METHODS: We enrolled 101 pSS patients with normal liver function and structures, and without significant liver diseases or other conditions affecting liver fibrosis. The European league against rheumatism (EULAR) SS patients reported index (ESSPRI) and the EULAR SS disease activity index (ESSDAI) were analyzed. Liver stiffness (LS) was measured using transient elastography and 7.4 kPa was determined as the cutoff value for significant liver fibrosis. RESULTS: The median age of patients (91women) was 53 years and the median LS value was 4.7 kPa. The median ESSPRI and ESSDAI showed no correlation with LS values. Twelve patients (11.9%) had significant liver fibrosis. In multivariate logistic regression, white blood cells count ≤4000.0/mm(3) (Odds ratio [OR] 9.821), serum albumin ≤3.8 mg/dL (OR 16.770) and aspartate aminotransferase (AST) ≥ 27.0 IU/L (OR 20.858) independently predicted silent but substantial liver fibrosis in pSS patients. CONCLUSIONS: The prevalence of silent but substantial liver fibrosis was 11.9% in pSS and its predictors were leukopenia, decreased serum albumin and increased AST levels.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Yong Beom(박용범)
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Song, Jungsik Jason(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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