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Hemostatic Markers and Long-Term Risk of Intracerebral Hemorrhage in Postmenopausal Women.

Authors
 Ju-Mi Lee  ;  Juned Siddique  ;  Hyeon Chang Kim  ;  David Green  ;  Linda Van Horn  ;  Matthew Allison  ;  Sylvia Wassertheil-Smoller  ;  Philip Greenland 
Citation
 JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, Vol.25(7) : 1639-1643, 2016 
Journal Title
 JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 
ISSN
 1052-3057 
Issue Date
2016
MeSH
ADAMTS13 Protein/blood ; Age Factors ; Aged ; Biomarkers/blood ; Case-Control Studies ; Cerebral Hemorrhage/blood ; Cerebral Hemorrhage/etiology* ; Female ; Hemostasis* ; Humans ; Middle Aged ; Platelet Count ; Postmenopause* ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Sex Factors ; Time Factors ; Tissue Plasminogen Activator/blood ; United States ; Urokinase-Type Plasminogen Activator/blood ; von Willebrand Factor/analysis
Keywords
ADAMTS13 ; Cerebral hemorrhage ; plasminogen activators ; von Willebrand factor
Abstract
BACKGROUND: Known risk factors for intracerebral hemorrhage (ICH) include age, hypertension, smoking, alcohol intake, and anticoagulant use. Some previous reports have indicated that hemostatic factors measured many years before the onset of ICH might predict the later occurrence of ICH. The objective of this analysis was to test whether selected hemostatic factors measured years before the onset of ICH could identify patients at higher risk for future ICH. METHODS: We performed a nested case-control study within the Women's Health Initiative (WHI) cohort. Postmenopausal women aged 50-79 years (mean 68) at baseline (1993-1998) were enrolled at 40 Clinical Centers in the United States and followed for adjudicated ICH for a mean of 11.4 years. ICH cases (N = 75) and controls (N = 75) were matched on age, ethnicity, blood pressure, anticoagulant use, and treated hypertension. Stored blood samples from the baseline WHI examination were tested for von Willebrand factor (vWF), a disintegrin-like and metalloprotease domain with thrombospondin type-1 motif, number 13 (ADAMTS13), tissue plasminogen activator (t-PA), and urokinase plasminogen activator (u-PA). Platelet count, white blood cell count, and hemoglobin concentration were also measured. RESULTS: Mean baseline levels of vWF (1.03 and .95 U/mL), ADAMTS13 (1.0 and 1.1 µg/mL), vWF : ADAMTS13 ratio (.99 and .92), t-PA (14.75 and 14.80 IU/mL), and u-PA (.09 and .10 IU/mL) were not significantly different by case-control status. Significant differences were also not identified for platelet count, hemoglobin, white blood count, or reported alcohol use. CONCLUSION: None of the 4 baseline hemostatic factors nor the platelet count was predictive of future ICH risk in this long-term study of older postmenopausal women.
Full Text
http://www.sciencedirect.com/science/article/pii/S1052305716001555
DOI
10.1016/j.jstrokecerebrovasdis.2016.03.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Lee, Ju Mi(이주미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147025
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