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ABO 부적합 신 이식 전 치료적 혈장교환술 횟수의 예측 변수로서의 초기 ABO 항체 역가

Other Titles
 Initial ABO Antibody Titer as a Variable for Estimating Number of Therapeutic Plasma Exchange prior to ABO Incompatible Kidney Transplantation. 
Authors
 Jieun Kim  ;  Sinyoung Kim  ;  Myoung Soo Kim  ;  Yu Seun Kim  ;  Hyun Ok Kim 
Citation
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.27(1) : 22-30, 2016 
Journal Title
 Korean Journal of Blood Transfusion  (대한수혈학회지) 
ISSN
 1226-9336 
Issue Date
2016
Keywords
Plasma exchange ; Blood group incompatibility ; Kidney transplantation ; ABO antibodies
Abstract
Background: Therapeutic plasma exchange (TPE) for desensitization in ABO incompatible kidney transplantation (KT) has raised concerns regarding efficiency and safety. The purpose of this study was to determine the number of TPE prior to KT required to reach target titer for KT according to ABO blood groups. Methods: The distribution of ABO antibody (Ab) titer of 117 patients was investigated. The relationship between initial ABO Ab and number of TPEs required to reach target titer to ≤1:8 prior to KT was evaluated retrospectively according to blood groups and ABO Ab classes. Results: The initial IgG ABO Ab titers were the highest in blood O group recipients, and the average number± standard deviations (range) of TPEs performed prior to ABO incompatible KT was 3.0±1.1 (0∼5) in blood group A, 3.7±1.5 (0∼8) in blood group B, and 5.3±1.9 (2∼13) in blood group O, respectively. The best correlation was observed in the linear relationship between initial ABO Ab titer and number of TPEs required (y=0.6829x+ 0.0523, R2=0.946, x=log2 initial ABO Ab titer, y=number of TPE required), regardless of the specific ABO blood group. Conclusion: The number of TPEs can be highly deduced from initial ABO Ab titer and our developed equation in desensitization programs would help increase the efficiency of TPE and patient safety.
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DOI
10.17945/kjbt.2016.27.1.22
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김신영(Kim, Sin Young) ORCID logo https://orcid.org/0000-0002-2609-8945
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
김지은(Kim, Jieun)
김현옥(Kim, Hyun Ok) ORCID logo https://orcid.org/0000-0002-4964-1963
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147019
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