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Liver-directed treatments for liver metastasis from gastric adenocarcinoma: comparison between liver resection and radiofrequency ablation.

Authors
 Ali Guner  ;  Taeil Son  ;  In Cho  ;  In Gyu Kwon : Ji Yeong An  ;  Hyoung-Il Kim  ;  Jae-Ho Cheong  ;  Sung Hoon Noh  ;  Woo Jin Hyung 
Citation
 GASTRIC CANCER, Vol.19(3) : 951-960, 2016 
Journal Title
 GASTRIC CANCER 
ISSN
 1436-3291 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Catheter Ablation* ; Female ; Follow-Up Studies ; Hepatectomy* ; Humans ; Liver Neoplasms/secondary* ; Liver Neoplasms/surgery* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Prognosis ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery* ; Survival Rate
Keywords
Gastric cancer ; Liver metastasis ; Liver resection ; Prognosis ; Radiofrequency ablation
Abstract
BACKGROUND: Although various liver-directed treatment modalities, such as liver resection and radiofrequency ablation (RFA), have been applied to treat liver metastases from gastric cancer, optimal management of them remains controversial. In patients with liver metastasis from gastric cancer, we investigated the short- and long-term outcomes of liver resection and RFA and analyzed factors influencing survival. METHODS: A total of 98 gastric cancer patients with liver metastasis and no extrahepatic disease were treated by liver resection (n = 68) or RFA (n = 30). Short- and long-term outcomes were evaluated retrospectively for each of the liver-directed treatments. RESULTS: Severe complication rates did not differ between liver resection (18 %) and RFA (10 %) (p = 0.333). Only one treatment-related mortality occurred in the liver resection group. No statistically significant difference in survival was noted between the treatment groups. Median overall survival after liver resection was 24 months, with 3-year overall and progression-free survival rates of 40.6 % and 30.4 %, respectively. Median overall survival after RFA was 23 months, with 3-year overall and progression-free survival rates of 43.0 % and 37.4 %, respectively. Only the size of the metastases was shown to be an independent prognostic factor for gastric cancer patients with liver metastasis. CONCLUSIONS: In select patients with liver metastasis from gastric cancer, liver resection and RFA showed satisfactory and comparable short- and long-term results. Thus, systemic chemotherapy may not be the only therapeutic option for patients with liver metastasis, and possible liver-directed treatment options for such patients should be considered on an individual basis.
Full Text
http://link.springer.com/article/10.1007/s10120-015-0522-z
DOI
10.1007/s10120-015-0522-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Son, Tae Il(손태일) ORCID logo https://orcid.org/0000-0002-0327-5224
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146982
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