Cited 18 times in
Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments.
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 김선호 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 이지현 | - |
dc.date.accessioned | 2017-02-27T07:42:05Z | - |
dc.date.available | 2017-02-27T07:42:05Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146966 | - |
dc.description.abstract | BACKGROUND: With the continuing development of new anti-cancer drugs comes a need for preclinical experimental models capable of predicting the clinical activity of these novel agents in cancer patients. However existing models have a limited ability to recapitulate the clinical characteristics and associated drug sensitivity of tumors. Among the more promising approaches for improving preclinical models is direct implantation of patient-derived tumor tissue into immunocompromised mice, such as athymic nude or non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice. In the current study, we attempted to develop patient-derived xenograft (PDX) models using tissue fragments from surgical samples of brain tumors. METHODS: In this approach, tiny tissue fragments of tumors were biopsied from eight brain tumor patients-seven glioblastoma patients and one primitive neuroectodermal tumor patient. Two administration methods-a cut-down syringe and a pipette-were used to implant tissue fragments from each patient into the brains of athymic nude mice. RESULTS: In contrast to previous reports, and contrary to our expectations, we found that none of these fragments from brain tumor biopsies resulted in the successful establishment of xenograft tumors. CONCLUSIONS: These results suggest that fragments of surgical specimens from brain tumor patients are unsuitable for implementation of brain tumor PDX models, and instead recommend other in vivo testing platforms for brain tumors, such as cell-based brain tumor models. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CANCER CELL INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Kyung‑Min Kim | - |
dc.contributor.googleauthor | Jin‑Kyoung Shim | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Ji‑Hyun Lee | - |
dc.contributor.googleauthor | Se‑Hoon Kim | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Junseong Park | - |
dc.contributor.googleauthor | Eui‑Hyun Kim | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.contributor.googleauthor | Yong‑Min Huh | - |
dc.contributor.googleauthor | Su‑Jae Lee | - |
dc.contributor.googleauthor | Jae‑Ho Cheong | - |
dc.contributor.googleauthor | Seok‑Gu Kang | - |
dc.identifier.doi | 10.1186/s12935-016-0319-0 | - |
dc.contributor.localId | A00036 | - |
dc.contributor.localId | A00560 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A03218 | - |
dc.relation.journalcode | J00436 | - |
dc.identifier.eissn | 1475-2867 | - |
dc.identifier.pmid | 27293382 | - |
dc.subject.keyword | Glioblastoma | - |
dc.subject.keyword | Model failure | - |
dc.subject.keyword | Patient-derived xenograft | - |
dc.subject.keyword | Primitive neuro-ectodermal tumor | - |
dc.subject.keyword | Tissue fragment | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Eui Hyun | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Eui Hyun | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hyun | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 43 | - |
dc.identifier.bibliographicCitation | CANCER CELL INTERNATIONAL, Vol.16 : 43, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46530 | - |
dc.type.rims | ART | - |
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