0 767

Cited 10 times in

Host immune responses to antigens derived from a predominant strain of Mycobacterium tuberculosis.

DC Field Value Language
dc.contributor.author김현숙-
dc.contributor.author조상래-
dc.contributor.author허윤경-
dc.date.accessioned2017-02-27T07:41:37Z-
dc.date.available2017-02-27T07:41:37Z-
dc.date.issued2016-
dc.identifier.issn0163-4453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146961-
dc.description.abstractOBJECTIVES: Beijing strain of Mycobacterium tuberculosis (M. tb) is characterized by a high incidence of transmission, relapse, and drug resistance. This study aimed to determine host immune responses to antigens derived from the Beijing/K strain which has been highly prevalent in tuberculosis (TB) outbreaks in South Korea. METHODS: We recruited 52 TB patients and 96 healthy subjects comprising 31 individuals with latent TB infection (LTBI) and 65 TB-naïve controls based on QuantiFERON-TB Gold In-Tube (QFT-IT) tests. Blood samples were obtained for diluted whole-blood assays, multiplex bead arrays, ELISpot assays, and HLA typing. Molecular genotyping of M. tb was performed using clinical isolates. RESULTS: Active TB and LTBI groups were differentiated by TNF-α concentrations induced by the Beijing/K strain-derived antigens, MTBK_24790 and MTBK_24800 (P < 0.001). MTBK_24800-induced IFN-γ and CXCL10 concentrations discriminated the TB-infected groups from TB-naïve controls (P < 0.001). IFN-γ-producing T cells were generated in 87.2% of TB patients in response to MTBK_24800 peptide antigens. The major immunogenic epitope was at C-terminal of the antigen, and predominantly recognized by HLA-DR4 and -DQ4. CONCLUSIONS: Measurement of IFN-γ, CXCL10, and TNF-α concentrations induced by MTBK_24790 and MTBK_24800 may contribute to improved diagnosis of TB and vaccine development in regions where the Beijing/K strain is endemic.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent54~62-
dc.languageEnglish-
dc.publisherW.B. Saunders-
dc.relation.isPartOfJOURNAL OF INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntigens, Bacterial/immunology*-
dc.subject.MESHCytokines/analysis-
dc.subject.MESHDisease Outbreaks-
dc.subject.MESHEpitopes, T-Lymphocyte/immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycobacterium tuberculosis/immunology*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHTuberculosis/diagnosis-
dc.subject.MESHTuberculosis/epidemiology-
dc.subject.MESHTuberculosis/microbiology*-
dc.subject.MESHYoung Adult-
dc.titleHost immune responses to antigens derived from a predominant strain of Mycobacterium tuberculosis.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorYun-Gyoung Hur-
dc.contributor.googleauthorWou Young Chung-
dc.contributor.googleauthorAhreum Kim-
dc.contributor.googleauthorYoung Sun Kim-
dc.contributor.googleauthorHyon-Suk Kim-
dc.contributor.googleauthorSun-Hee Jang-
dc.contributor.googleauthorYeun Kim-
dc.contributor.googleauthorHyeyoung Lee-
dc.contributor.googleauthorKwang Joo Park-
dc.contributor.googleauthorSang-Nae Cho-
dc.identifier.doi10.1016/j.jinf.2016.04.032-
dc.contributor.localIdA01117-
dc.contributor.localIdA03824-
dc.contributor.localIdA04701-
dc.relation.journalcodeJ01452-
dc.identifier.eissn1532-2742-
dc.identifier.pmid27155519-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0163445316300597-
dc.subject.keywordBeijing/K strain-
dc.subject.keywordCXCL10-
dc.subject.keywordIFN-γ-
dc.subject.keywordLatent TB infection-
dc.subject.keywordMycobacterium tuberculosis-
dc.subject.keywordTB-
dc.subject.keywordTNF-α-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.alternativeNameHur, Yun-Gyoung-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.contributor.affiliatedAuthorHur, Yun-Gyoung-
dc.citation.volume73-
dc.citation.number1-
dc.citation.startPage54-
dc.citation.endPage62-
dc.identifier.bibliographicCitationJOURNAL OF INFECTION, Vol.73(1) : 54-62, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46525-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.