Cited 10 times in
Host immune responses to antigens derived from a predominant strain of Mycobacterium tuberculosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 허윤경 | - |
dc.date.accessioned | 2017-02-27T07:41:37Z | - |
dc.date.available | 2017-02-27T07:41:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146961 | - |
dc.description.abstract | OBJECTIVES: Beijing strain of Mycobacterium tuberculosis (M. tb) is characterized by a high incidence of transmission, relapse, and drug resistance. This study aimed to determine host immune responses to antigens derived from the Beijing/K strain which has been highly prevalent in tuberculosis (TB) outbreaks in South Korea. METHODS: We recruited 52 TB patients and 96 healthy subjects comprising 31 individuals with latent TB infection (LTBI) and 65 TB-naïve controls based on QuantiFERON-TB Gold In-Tube (QFT-IT) tests. Blood samples were obtained for diluted whole-blood assays, multiplex bead arrays, ELISpot assays, and HLA typing. Molecular genotyping of M. tb was performed using clinical isolates. RESULTS: Active TB and LTBI groups were differentiated by TNF-α concentrations induced by the Beijing/K strain-derived antigens, MTBK_24790 and MTBK_24800 (P < 0.001). MTBK_24800-induced IFN-γ and CXCL10 concentrations discriminated the TB-infected groups from TB-naïve controls (P < 0.001). IFN-γ-producing T cells were generated in 87.2% of TB patients in response to MTBK_24800 peptide antigens. The major immunogenic epitope was at C-terminal of the antigen, and predominantly recognized by HLA-DR4 and -DQ4. CONCLUSIONS: Measurement of IFN-γ, CXCL10, and TNF-α concentrations induced by MTBK_24790 and MTBK_24800 may contribute to improved diagnosis of TB and vaccine development in regions where the Beijing/K strain is endemic. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 54~62 | - |
dc.language | English | - |
dc.publisher | W.B. Saunders | - |
dc.relation.isPartOf | JOURNAL OF INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antigens, Bacterial/immunology* | - |
dc.subject.MESH | Cytokines/analysis | - |
dc.subject.MESH | Disease Outbreaks | - |
dc.subject.MESH | Epitopes, T-Lymphocyte/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Tuberculosis/diagnosis | - |
dc.subject.MESH | Tuberculosis/epidemiology | - |
dc.subject.MESH | Tuberculosis/microbiology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Host immune responses to antigens derived from a predominant strain of Mycobacterium tuberculosis. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Yun-Gyoung Hur | - |
dc.contributor.googleauthor | Wou Young Chung | - |
dc.contributor.googleauthor | Ahreum Kim | - |
dc.contributor.googleauthor | Young Sun Kim | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.contributor.googleauthor | Sun-Hee Jang | - |
dc.contributor.googleauthor | Yeun Kim | - |
dc.contributor.googleauthor | Hyeyoung Lee | - |
dc.contributor.googleauthor | Kwang Joo Park | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.1016/j.jinf.2016.04.032 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A04701 | - |
dc.relation.journalcode | J01452 | - |
dc.identifier.eissn | 1532-2742 | - |
dc.identifier.pmid | 27155519 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0163445316300597 | - |
dc.subject.keyword | Beijing/K strain | - |
dc.subject.keyword | CXCL10 | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | Latent TB infection | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | TB | - |
dc.subject.keyword | TNF-α | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Hur, Yun-Gyoung | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Hur, Yun-Gyoung | - |
dc.citation.volume | 73 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 62 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION, Vol.73(1) : 54-62, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46525 | - |
dc.type.rims | ART | - |
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