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Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer.

Authors
 Daham Kim  ;  Woo Kyung Lee  ;  Seonhyang Jeong  ;  Mi-Youn Seol  ;  Hyunji Kim  ;  Kyung-Sup Kim  ;  Eun Jig Lee  ;  Jandee Lee  ;  Young Suk Jo 
Citation
 MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol.431 : 36-45, 2016 
Journal Title
 MOLECULAR AND CELLULAR ENDOCRINOLOGY 
ISSN
 0303-7207 
Issue Date
2016
MeSH
Cell Line ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lymphatic Metastasis/genetics ; Polymorphism, Single Nucleotide/genetics ; RNA, Long Noncoding/genetics* ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/pathology* ; Up-Regulation/genetics*
Keywords
Carcinogenesis ; LOC100507661 ; Long noncoding RNA ; Thyroid cancer
Abstract
Recent advances in next-generation sequencing have revealed a variety of long noncoding RNAs (lncRNAs). However, studies of lncRNAs are at a very early stage, our knowledge of the biological functions and clinical implications remains limited. To investigate the roles of lncRNAs in thyroid cancers, we verified 56 lncRNAs identified as potential cancer-promoting genes in a previous study that analyzed 2394 tumor SNP arrays from 12 types of cancer. Based on verified sequence information in NCBI and Ensembl, we ultimately selected three candidate lncRNAs for detailed analysis. One of the candidates, LOC100507661, was strongly upregulated in thyroid cancer tissues relative to paired contralateral normal tissue. LOC100507661 was easily detectable in papillary and anaplastic thyroid cancer cell lines such as TPC1, BCPAP, C643, and 8505C, but not in the follicular thyroid cancer cell line FTC133. Stable overexpression of LOC100507661 promoted cell proliferation, migration, and invasion of thyroid cancer cells. Lymph node metastasis and BRAF V600E mutations were more frequent in papillary thyroid cancers with high LOC100507661 expression. Our data demonstrate that LOC100507661 expression is elevated in human thyroid cancer and may play a critical role in thyroid carcinogenesis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0303720716301502
DOI
10.1016/j.mce.2016.05.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Lee, Woo Kyung(이우경) ORCID logo https://orcid.org/0000-0002-6737-3173
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Jan Dee(이잔디) ORCID logo https://orcid.org/0000-0003-4090-0049
Jeong, Seonhyang(정선향) ORCID logo https://orcid.org/0000-0002-5549-9182
Jo, Young Suk(조영석) ORCID logo https://orcid.org/0000-0001-9926-8389
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146920
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