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Role of OCT-1 and partner proteins in T cell differentiation.

Authors
 Soo Seok Hwang  ;  Lark Kyun Kim  ;  Gap Ryol Lee  ;  Richard A. Flavell 
Citation
 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, Vol.1859(6) : 825-831, 2016 
Journal Title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
ISSN
 1874-9399 
Issue Date
2016
MeSH
CCCTC-Binding Factor ; CD4-Positive T-Lymphocytes/cytology* ; CD4-Positive T-Lymphocytes/immunology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Chromatin/chemistry ; Chromatin/metabolism* ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/immunology ; Cytokines/genetics ; Cytokines/immunology ; Gene Expression Regulation* ; Humans ; Lymphocyte Activation ; Octamer Transcription Factor-1/genetics* ; Octamer Transcription Factor-1/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/immunology ; Signal Transduction ; T-Lymphocyte Subsets/cytology* ; T-Lymphocyte Subsets/immunology ; Trans-Activators/genetics ; Trans-Activators/immunology
Keywords
CD4 T cell differentiation ; CTCF ; Chromosomal association ; Cohesin ; Gene regulation ; OCA-B ; OCT-1 ; Transcription factor
Abstract
The understanding of CD4 T cell differentiation gives important insights into the control of immune responses against various pathogens and in autoimmune diseases. Naïve CD4 T cells become effector T cells in response to antigen stimulation in combination with various environmental cytokine stimuli. Several transcription factors and cis-regulatory regions have been identified to regulate epigenetic processes on chromatin, to allow the production of proper effector cytokines during CD4 T cell differentiation. OCT-1 (Pou2f1) is well known as a widely expressed transcription factor in most tissues and cells. Although the importance of OCT-1 has been emphasized during development and differentiation, its detailed molecular underpinning and precise role are poorly understood. Recently, a series of studies have reported that OCT-1 plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions. In this review, we will describe the role of OCT-1 in CD4 T cell differentiation and discuss how this factor orchestrates the fate and function of CD4 effector T cells.
Full Text
http://www.sciencedirect.com/science/article/pii/S1874939916300682
DOI
10.1016/j.bbagrm.2016.04.006
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146883
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