Cited 14 times in
Role of OCT-1 and partner proteins in T cell differentiation.
DC Field | Value | Language |
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dc.contributor.author | 김락균 | - |
dc.date.accessioned | 2017-02-27T07:26:57Z | - |
dc.date.available | 2017-02-27T07:26:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1874-9399 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146883 | - |
dc.description.abstract | The understanding of CD4 T cell differentiation gives important insights into the control of immune responses against various pathogens and in autoimmune diseases. Naïve CD4 T cells become effector T cells in response to antigen stimulation in combination with various environmental cytokine stimuli. Several transcription factors and cis-regulatory regions have been identified to regulate epigenetic processes on chromatin, to allow the production of proper effector cytokines during CD4 T cell differentiation. OCT-1 (Pou2f1) is well known as a widely expressed transcription factor in most tissues and cells. Although the importance of OCT-1 has been emphasized during development and differentiation, its detailed molecular underpinning and precise role are poorly understood. Recently, a series of studies have reported that OCT-1 plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions. In this review, we will describe the role of OCT-1 in CD4 T cell differentiation and discuss how this factor orchestrates the fate and function of CD4 effector T cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 825~831 | - |
dc.publisher | Elsevier Pub. Co. | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | CCCTC-Binding Factor | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/cytology* | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Cell Cycle Proteins/genetics | - |
dc.subject.MESH | Cell Cycle Proteins/immunology | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Lineage/immunology | - |
dc.subject.MESH | Chromatin/chemistry | - |
dc.subject.MESH | Chromatin/metabolism* | - |
dc.subject.MESH | Chromosomal Proteins, Non-Histone/genetics | - |
dc.subject.MESH | Chromosomal Proteins, Non-Histone/immunology | - |
dc.subject.MESH | Cytokines/genetics | - |
dc.subject.MESH | Cytokines/immunology | - |
dc.subject.MESH | Gene Expression Regulation* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Octamer Transcription Factor-1/genetics* | - |
dc.subject.MESH | Octamer Transcription Factor-1/metabolism | - |
dc.subject.MESH | Repressor Proteins/genetics | - |
dc.subject.MESH | Repressor Proteins/immunology | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | T-Lymphocyte Subsets/cytology* | - |
dc.subject.MESH | T-Lymphocyte Subsets/immunology | - |
dc.subject.MESH | Trans-Activators/genetics | - |
dc.subject.MESH | Trans-Activators/immunology | - |
dc.title | Role of OCT-1 and partner proteins in T cell differentiation. | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Soo Seok Hwang | - |
dc.contributor.googleauthor | Lark Kyun Kim | - |
dc.contributor.googleauthor | Gap Ryol Lee | - |
dc.contributor.googleauthor | Richard A. Flavell | - |
dc.identifier.doi | 10.1016/j.bbagrm.2016.04.006 | - |
dc.contributor.localId | A04520 | - |
dc.relation.journalcode | J00288 | - |
dc.identifier.eissn | 1878-2434 | - |
dc.identifier.pmid | 27126747 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1874939916300682 | - |
dc.subject.keyword | CD4 T cell differentiation | - |
dc.subject.keyword | CTCF | - |
dc.subject.keyword | Chromosomal association | - |
dc.subject.keyword | Cohesin | - |
dc.subject.keyword | Gene regulation | - |
dc.subject.keyword | OCA-B | - |
dc.subject.keyword | OCT-1 | - |
dc.subject.keyword | Transcription factor | - |
dc.contributor.alternativeName | Kim, Lark Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Lark Kyun | - |
dc.citation.volume | 1859 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 825 | - |
dc.citation.endPage | 831 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, Vol.1859(6) : 825-831, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46450 | - |
dc.type.rims | ART | - |
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