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Selection of a mobilization regimen for multiple myeloma based on the response to induction therapy: granulocyte-colony stimulating factor (G-CSF) alone versus high-dose cyclophosphamide plus G-CSF.

Authors
 Ji Eun Jang  ;  June-Won Cheong  ;  Soo-Jeong Kim  ;  Hyunsoo Cho  ;  Cheolwon Suh  ;  Hyewon Lee  ;  Hyeon-Seok Eom  ;  Ho-Young Yhim  ;  Won-Sik Lee  ;  Chang-Ki Min  ;  Jae Hoon Lee  ;  Joon Seong Park  ;  Jin Seok Kim 
Citation
 LEUKEMIA & LYMPHOMA, Vol.57(6) : 1389-1397, 2016 
Journal Title
 LEUKEMIA & LYMPHOMA 
ISSN
 1042-8194 
Issue Date
2016
MeSH
Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Cyclophosphamide/administration & dosage ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cell Mobilization*/methods ; Hematopoietic Stem Cell Transplantation* ; Humans ; Male ; Middle Aged ; Multiple Myeloma/diagnosis ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy* ; Remission Induction ; Transplantation Conditioning*/adverse effects ; Transplantation Conditioning*/methods ; Transplantation, Autologous ; Treatment Outcome
Keywords
Cyclophosphamide ; granulocyte-colony stimulating factor ; multiple myeloma ; stem cell mobilization
Abstract
To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. In comparison with patients who achieved at least a very good partial response (VGPR) to induction therapy and received granulocyte-colony stimulating factor (G-CSF) alone and patients who did not achieve a VGPR and received cyclophosphamide (CY) + G-CSF, treatment-related toxicity was greater and neutrophil engraftment was slower in the CY than the G-CSF group. The rate of requisite mobilization (≥ 2.0 × 10(6)/kg) was similar in both groups. Overall and progression-free survival was not different between patients in the G-CSF group and patients who achieved at least VGPR and received CY + G-CSF. In conclusion, response-adapted selection of a mobilization regimen is appropriate. G-CSF alone should be the preferred treatment for patients who achieved at least a VGPR to induction therapy.
Full Text
http://www.tandfonline.com/doi/abs/10.3109/10428194.2015.1102240
DOI
10.3109/10428194.2015.1102240
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Jang, Ji Eun(장지은) ORCID logo https://orcid.org/0000-0001-8832-1412
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146877
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