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Renal denervation for treatment of uncontrolled hypertension in an Asian population: results from the Global SYMPLICITY Registry in South Korea (GSR Korea).

Authors
 B-K Kim  ;  M Böhm  ;  F Mahfoud  ;  G Mancia  ;  S Park  ;  M-K Hong  ;  H-S Kim  ;  S-J Park  ;  CG Park  ;  KB Seung  ;  H-C Gwon  ;  D-J Choi  ;  TH Ahn  ;  CJ Kim  ;  HM Kwon  ;  M Esler  ;  YS Jang 
Citation
 JOURNAL OF HUMAN HYPERTENSION, Vol.30(5) : 315-321, 2016 
Journal Title
 JOURNAL OF HUMAN HYPERTENSION 
ISSN
 0950-9240 
Issue Date
2016
MeSH
Adult ; Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Catheter Ablation/statistics & numerical data* ; Denervation/statistics & numerical data* ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/surgery* ; Male ; Middle Aged ; Prospective Studies ; Registries* ; Renal Artery/innervation* ; Treatment Outcome
Abstract
Reports detailing the response of hypertensive patients to renal denervation (RDN) in Asian patients are limited. We evaluated 6- and 12-month outcomes after RDN in an Asian population and compared outcomes to a primarily Caucasian population. The Global SYMPLICITY Registry (GSR) is a prospective, all-comer, worldwide registry that evaluates the safety and effectiveness of RDN and includes the Korean registry substudy (GSR Korea) and a Caucasian subset (GSR Caucasian). Given differences in baseline characteristics among GSR Korea (n=93) as compared with GSR Caucasian (n=169) patients, including lower baseline office systolic blood pressure (SBP), lower body mass index and differences in medications, propensity score adjustment was performed when comparing the change in SBP between subsets. The 6- and 12-month change in SBP in GSR Korea was -19.4±17.2 and -27.2±18.1 mm Hg, respectively (P<0.001 for both vs baseline). GSR Caucasian had a SBP change similar to GSR Korea at 6 months (-20.9±21.4 mm Hg, unadjusted P=0.547, adjusted P=0.998), whereas at 12 months the change was significantly less pronounced (-20.1±23.9 mm Hg, unadjusted P=0.004, adjusted P=0.002). There were no protocol-defined procedure-related adverse events and no chronic adverse events associated with the device in an Asian population. RDN provided a significant reduction in 6- and 12-month office SBP among Asian patients, with a favorable safety profile. The 12-month SBP reduction was larger than that observed in Caucasian patients.
Full Text
http://www.nature.com/jhh/journal/v30/n5/full/jhh201577a.html
DOI
10.1038/jhh.2015.77
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146868
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