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Subclassification of Barcelona Clinic Liver Cancer B and C hepatocellular carcinoma: A cohort study of the multicenter registry database.

 Sangheun Lee  ;  Beom Kyung Kim  ;  Kijun Song  ;  Jun Yong Park  ;  Sang Hoon Ahn  ;  Seung Up Kim  ;  Kwang-Hyub Han  ;  Do Young Kim  ;  Korea Central Cancer Registry 
 Journal of Gastroenterology and Hepatology, Vol.31(4) : 842-847, 2016 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
Aged ; Carcinoma, Hepatocellular/classification* ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology* ; Cohort Studies ; Databases as Topic* ; Female ; Forecasting ; Humans ; Liver Neoplasms/classification* ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology* ; Male ; Middle Aged ; Multicenter Studies as Topic* ; Neoplasm Staging ; Prognosis ; Registries* ; Survival Rate
Barcelona Clinic Liver Cancer stage ; hepatocellular carcinoma ; overall survival ; prognosis ; subclassification
BACKGROUND AND AIM: We aimed to subclassify hepatocellular carcinoma (HCC) using Barcelona Clinic Liver Cancer intermediate and advanced stages, which include a highly heterogeneous population. METHODS: From two registries ("random" and "voluntary" cohorts in the Korean Liver Cancer Study Group), patients who were newly diagnosed as HCC with intermediate or advanced stage between 2003 and 2005 were considered eligible. Overall survival (OS) was analyzed using Kaplan-Meier method with comparison by log-rank test. RESULTS: Patients with intermediate-stage HCC (n = 994) were subclassified according to tumor size and Child-Pugh class. Patients with tumor size < 5 cm (B1), those with tumor size ≥ 5 cm and Child-Pugh A (B2), and those with tumor size ≥ 5 cm and Child-Pugh B (B3) had median OS of 30.73, 20.60, and 9.23 months, respectively (P < 0.001 by log-rank test). Among patients with advanced stage HCC (n = 1746), patients were subclassified according to presence of significant portal vein invasion (sPVI; defined as portal vein invasion in lobar, main, or contralateral branch) and extrahepatic spread (EHS). Patients with neither sPVI nor EHS (C1), those with either sPVI or EHS (C2), and those with both sPVI and EHS (C3) had median OS of 8.43, 4.63, and 3.63 months, respectively (P < 0.001 by log-rank test). CONCLUSION: Subclassification of Barcelona Clinic Liver Cancer intermediate and advanced stages might be useful for determining patient prognosis and guiding treatment strategies for HCC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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