Cited 21 times in
Pulmonary immunity and durable protection induced by the ID93/GLA-SE vaccine candidate against the hyper-virulent Korean Beijing Mycobacterium tuberculosis strain K
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종석 | - |
dc.contributor.author | 신성재 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 차승빈 | - |
dc.date.accessioned | 2017-02-24T11:41:15Z | - |
dc.date.available | 2017-02-24T11:41:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146835 | - |
dc.description.abstract | The majority of tuberculosis (TB) vaccine candidates advanced to clinical trials have been evaluated preclinically using laboratory-adapted strains. However, it has been proposed that challenge with clinical isolates in preclinical vaccine testing could provide further and more practical validation. Here, we tested the ID93/GLA-SE TB vaccine candidate against the clinical Mycobacterium tuberculosis (Mtb) strain K (Mtb K) belonging to the Beijing family, the most prevalent Mtb strain in South Korea. Mice immunized with ID93/GLA-SE exhibited a significant reduction in bacteria and reduced lung inflammation against Mtb K when compared to non-immunized controls. In addition, we analyzed the immune responses in the lungs of ID93/GLA-SE-immunized mice, and showed that ID93/GLA-SE was able to elicit sustained Th1-biased immune responses including antigen-specific multifunctional CD4(+) T cell co-producing IFN-γ, TNF-α, and IL-2 as well as a high magnitude of IFN-γ response for up to 10 weeks post-challenge. Notably, further investigation of T cell subsets in the lung following challenge showed remarkable generation of CD8(+) central memory T cells by ID93/GLA-SE-immunization. Our findings showed that ID93/GLA-SE vaccine confers a high level of robust protection against the hypervirulent Mtb Beijing infection which was characterized by pulmonary Th1-polarized T-cell immune responses. These findings may also provide relevant information for potential utility of this vaccine candidate in East-Asian countries where the Beijing genotype is highly prevalent. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 2179~2187 | - |
dc.language | VACCINE | - |
dc.publisher | VACCINE | - |
dc.relation.isPartOf | VACCINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Load | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunologic Memory | - |
dc.subject.MESH | Interferon-gamma/immunology | - |
dc.subject.MESH | Interleukin-2/immunology | - |
dc.subject.MESH | Lung/immunology* | - |
dc.subject.MESH | Lung/microbiology | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mycobacterium tuberculosis/classification | - |
dc.subject.MESH | Spleen/immunology | - |
dc.subject.MESH | Spleen/microbiology | - |
dc.subject.MESH | Tuberculosis/immunology | - |
dc.subject.MESH | Tuberculosis/prevention & control* | - |
dc.subject.MESH | Tuberculosis Vaccines/immunology* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/immunology | - |
dc.title | Pulmonary immunity and durable protection induced by the ID93/GLA-SE vaccine candidate against the hyper-virulent Korean Beijing Mycobacterium tuberculosis strain K | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | Researcher Institutes | - |
dc.contributor.department | Institute for Immunology and Immunological Disease | - |
dc.contributor.googleauthor | Seung Bin Cha | - |
dc.contributor.googleauthor | Woo Sik Kim | - |
dc.contributor.googleauthor | Jong-Seok Kim | - |
dc.contributor.googleauthor | Hongmin Kim | - |
dc.contributor.googleauthor | Kee Woong Kwon | - |
dc.contributor.googleauthor | Seung Jung Han | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Rhea N. Coler | - |
dc.contributor.googleauthor | Steven G. Reed | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.1016/j.vaccine.2016.03.029 | - |
dc.contributor.localId | A00920 | - |
dc.contributor.localId | A02114 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A03998 | - |
dc.relation.journalcode | J02776 | - |
dc.identifier.eissn | 1358-8745 | - |
dc.identifier.pmid | 27005808 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0264410X16003406 | - |
dc.subject.keyword | Beijing family | - |
dc.subject.keyword | GLA-SE | - |
dc.subject.keyword | ID93 | - |
dc.subject.keyword | K strain | - |
dc.subject.keyword | Tuberculosis | - |
dc.contributor.alternativeName | Kim, Jong Seok | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Cha, Seung Bin | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seok | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cha, Seung Bin | - |
dc.citation.volume | 34 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 2179 | - |
dc.citation.endPage | 2187 | - |
dc.identifier.bibliographicCitation | VACCINE, Vol.34(19) : 2179-2187, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47577 | - |
dc.type.rims | ART | - |
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